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Chrna2
Gene Detail
 Symbol
Name
ID
Chrna2
cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)
MGI:87886
Synonyms Acra2, Acra-2, MGC:18795
Feature Type protein coding gene
Genetic Map
Chromosome 14
34.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:66140960-66152948 bp, + strand
From VEGA annotation of GRCm38

  11989 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20193  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Chrna2

Human
homologs
Human Homolog CHRNA2, cholinergic receptor, nicotinic, alpha 2 (neuronal)
NCBI Gene ID 1135
neXtProt AC  NX_Q15822
Human Chr (Location)  8p21; chr8:27459761-27479296 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CHRNA2
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation do not exhibit any significant abnormalities compared to controls.
 
Interactions
Chrna2 interacts with 243 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cation transmembrane transport, cation transport, ...
Component acetylcholine-gated channel complex, cell junction, ...
Function acetylcholine-activated cation-selective channel activity, acetylcholine binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (174)    Tissues (109)    Images (21)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 75
In situ reporter (knock in) 36
Northern blot 8
RT-PCR 55
cDNA source data(2)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(4) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000039812 (Evidence)
Ensembl Gene ModelENSMUSG00000022041 (Evidence)
Entrez Gene110902 (Evidence)
UniGene57350
DFCITC1590138
DoTSDT.55116799
NIA Mouse Gene IndexU015784
Consensus CDS ProjectCCDS27219.1
International Mouse Knockout Project StatusChrna2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039812 VEGA Gene Model | MGI Sequence Detail 11989 C57BL/6J ±  kb
transcript OTTMUST00000103500 VEGA | MGI Sequence Detail 3527 Not Applicable 
polypeptide OTTMUSP00000057835 VEGA | MGI Sequence Detail 512 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(12) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(91 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
InterPro IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
InterPro IPR002394 Nicotinic acetylcholine receptor
Protein Ontology PR:000005455 neuronal acetylcholine receptor subunit alpha-2
References (Earliest) J:10489 Bessis A, et al., Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor. FEBS Lett. 1990 May 7;264(1):48-52
(Latest) J:201684 Lamotte d'Incamps B, et al., Subunit composition and kinetics of the Renshaw cell heteromeric nicotinic receptors. Biochem Pharmacol. 2013 Oct 15;86(8):1114-21
All references(42)
Other
accession IDs
MGD-MRK-1055, MGD-MRK-1059, MGI:2384825

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory