About   Help   FAQ
Chrna2
Gene Detail
Symbol

Name
ID
Chrna2
cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)
MGI:87886
Synonyms
Acra2, Acra-2, MGC:18795
Feature Type
protein coding gene
Genetic Map
Chromosome 14
34.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:66140960-66152948 bp, + strand
From VEGA annotation of GRCm38

  11989 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20193  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: CHRNA2
Gene Tree: Chrna2

Human
homologs
CHRNA2, cholinergic receptor, nicotinic, alpha 2 (neuronal)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1135
neXtProt AC: NX_Q15822

Human Chr (Location): 8p21; chr8:27459761-27479296 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CHRNA2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted null mutation do not exhibit any significant abnormalities compared to controls.
 
Interactions
Chrna2 interacts with 242 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (174)    Tissues (109)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 75
In situ reporter (knock in) 36
Northern blot 8
RT-PCR 55
cDNA source data(2)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: ZFIN chrna2a, chrna2b    NEW 
Molecular
reagents
All nucleic(6) cDNA(4) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000039812 (Evidence)
Ensembl Gene Model ENSMUSG00000022041 (Evidence)
Entrez Gene 110902 (Evidence)
UniGene 57350
DFCI TC1590138
DoTS DT.55116799
NIA Mouse Gene Index U015784
Consensus CDS Project CCDS27219.1
International Mouse Phenotyping Consortium Status Chrna2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039812 VEGA Gene Model | MGI Sequence Detail 11989 C57BL/6J ±  kb
transcript OTTMUST00000103500 VEGA | MGI Sequence Detail 3527 Not Applicable 
polypeptide OTTMUSP00000057835 VEGA | MGI Sequence Detail 512 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(12) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(91 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
InterPro IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
InterPro IPR002394 Nicotinic acetylcholine receptor
Protein Ontology PR:000005455 neuronal acetylcholine receptor subunit alpha-2
References
(Earliest) J:10489 Bessis A, et al., Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor. FEBS Lett. 1990 May 7;264(1):48-52
(Latest) J:209670 Martinez-Pena y Valenzuela I, et al., PKC and PKA regulate AChR dynamics at the neuromuscular junction of living mice. PLoS One. 2013;8(11):e81311
All references(40)
Other
accession IDs
MGD-MRK-1055, MGD-MRK-1059, MGI:2384825

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory