Chrna2
Gene Detail

Symbol Name ID

Chrna2 cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) MGI:87886

Synonyms

Acra2, Acra-2, MGC:18795

Feature Type

protein coding gene

Genetic Map

Chromosome 14

34.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:66140960-66152948 bp, + strand From VEGA annotation of GRCm38   11989 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Chrna2 ± 2 cM)

Gene Tree: Chrna2

Human ortholog

CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) NCBI Gene ID 1135
Human Chr8:27317278-27336813 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human CHRNA2 (1)

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a targeted null mutation do not exhibit any significant abnormalities compared to controls.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	ion transport, protein heterooligomerization, ...
Component	acetylcholine-gated channel complex, cell junction, ...
Function	acetylcholine-activated cation-selective channel activity, acetylcholine binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (125)    Tissues (58)    Images (19)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	26
In situ reporter (knock in)	36
Northern blot	8
RT-PCR	55

cDNA source data(2)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(4) Primer pair(2)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000039812 (Evidence)
Ensembl Gene Model	ENSMUSG00000022041 (Evidence)
Entrez Gene	110902 (Evidence)
UniGene	57350
DFCI	TC1590138
DoTS	DT.55116799
NIA Mouse Gene Index	U015784
Consensus CDS Project	CCDS27219.1
International Mouse Knockout Project Status	Chrna2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000039812	VEGA Gene Model | MGI Sequence Detail	11989	C57BL/6J
transcript	OTTMUST00000103500	VEGA | MGI Sequence Detail	3527	Not Applicable
polypeptide	OTTMUSP00000057835	VEGA | MGI Sequence Detail	512	Not Applicable

All sequences(17) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(80 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006201	Neurotransmitter-gated ion-channel
InterPro	IPR018000	Neurotransmitter-gated ion-channel, conserved site
InterPro	IPR006202	Neurotransmitter-gated ion-channel ligand-binding
InterPro	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
InterPro	IPR002394	Nicotinic acetylcholine receptor
Protein Ontology	PR:000005455	neuronal acetylcholine receptor subunit alpha-2

References

(Earliest) J:10489 Bessis A, et al., Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor. FEBS Lett. 1990 May 7;264(1):48-52
(Latest) J:190149 Bajayo A, et al., Skeletal parasympathetic innervation communicates central IL-1 signals regulating bone mass accrual. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15455-60
All references(39)

Other accession IDs

MGD-MRK-1055, MGD-MRK-1059, MGI:2384825