About   Help   FAQ
Acr Gene Detail
Summary
  • Symbol
    Acr
  • Name
    acrosin prepropeptide
  • Synonyms
    preproacrosin
  • Feature Type
    protein coding gene
  • IDs
    MGI:87884
    NCBI Gene: 11434
  • Gene Overview
    MyGene.info: ACR
Location & Maps
more
  • Sequence Map
    Chr15:89568326-89574585 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6260 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ACR, acrosin
  • Vertebrate Orthologs
    23
  • Human Ortholog
    ACR, acrosin
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 49
    neXtProt AC: NX_P10323

  • Chr Location
    22q13.33; chr22:50738224-50745299 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 855
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;2 chicken;14 western clawed frog
  • HCOP
    human homology predictions: ACR
  • Protein SuperFamily
  • Gene Tree
    Acr
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    3 involving Acr
  • Incidental Mutations
Males homozygous for a targeted null mutation produce sperm that shows delayed fertilization in vitro. Sperm from mutant gonial cells are ineffective at fertilization in competition with normal sperm both in vitro and in vivo.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022622 Ensembl Gene Model | MGI Sequence Detail 6260 C57BL/6J ±  kb
transcript ENSMUST00000023295 Ensembl | MGI Sequence Detail 1504 Not Applicable  
polypeptide ENSMUSP00000023295 Ensembl | MGI Sequence Detail 436 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    189 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    Genomic 3
    cDNA 18
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1053, MGI:2145978
References
more
  • Summaries
    All 55
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 12
    Phenotypes 30
  • Earliest
    J:10505 Klemm U, et al., Mouse preproacrosin: cDNA sequence, primary structure and postmeiotic expression in spermatogenesis. Differentiation. 1990 Feb;42(3):160-6
  • Latest
    J:202077 Kanemori Y, et al., Two functional forms of ACRBP/sp32 are produced by pre-mRNA alternative splicing in the mouse. Biol Reprod. 2013 Apr;88(4):105

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory