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Acads Gene Detail
Summary
  • Symbol
    Acads
  • Name
    acyl-Coenzyme A dehydrogenase, short chain
  • Synonyms
    Bcd1, Bcd-1, Hdlq8, SCAD
  • Feature Type
    protein coding gene
  • IDs
    MGI:87868
    NCBI Gene: 11409
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:115110299-115119346 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 55.99 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87868
protein coding gene Chr5:115110299-115119346 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029957
protein coding gene Chr5:117942419-117952210 (-)
A/J MGP_AJ_G0029922
protein coding gene Chr5:113268693-113277840 (-)
AKR/J MGP_AKRJ_G0029860
protein coding gene Chr5:116877950-116887693 (-)
BALB/cJ MGP_BALBcJ_G0029933
protein coding gene Chr5:114668733-114679386 (-)
C3H/HeJ MGP_C3HHeJ_G0029652
protein coding gene Chr5:117401334-117412148 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030387
protein coding gene Chr5:122493722-122502773 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027614
protein coding gene Chr5:108049263-108057361 (-)
CAST/EiJ MGP_CASTEiJ_G0029061
protein coding gene Chr5:116322303-116333414 (-)
CBA/J MGP_CBAJ_G0029620
protein coding gene Chr5:127184449-127193534 (-)
DBA/2J MGP_DBA2J_G0029770
protein coding gene Chr5:113341810-113351008 (-)
FVB/NJ MGP_FVBNJ_G0029726
protein coding gene Chr5:112156399-112166560 (-)
LP/J MGP_LPJ_G0029858
protein coding gene Chr5:118511637-118524169 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029757
protein coding gene Chr5:131528324-131538805 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030428
protein coding gene Chr5:116354628-116365256 (-)
PWK/PhJ MGP_PWKPhJ_G0028774
protein coding gene Chr5:112004475-112016571 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028612
protein coding gene Chr5:113903622-113912834 (-)
WSB/EiJ MGP_WSBEiJ_G0029136
protein coding gene Chr5:116938156-116950930 (-)



Homology
more
  • Human Ortholog
    ACADS, acyl-CoA dehydrogenase short chain
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACADS, acyl-CoA dehydrogenase short chain
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACAD3, SCAD
  • Links
    NCBI Gene ID: 35
    neXtProt AC: NX_P16219
    UniProt: P16219

  • Chr Location
    12q24.31; chr12:120725738-120740008 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20057
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ACADS
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Acads mouse models; 1 with human ACADS associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display organic aciduria and develop hypoglycemia and fatty livers after fasting.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11409 NCBI Gene Model | MGI Sequence Detail 9048 C57BL/6J ±  kb
    transcript NM_007383 RefSeq | MGI Sequence Detail 1881 C57BL/6  
    polypeptide Q07417 UniProt | EBI | MGI Sequence Detail 412 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000003602 short-chain specific acyl-CoA dehydrogenase, mitochondrial
    • EC
    • InterPro Domains
      IPR006089 Acyl-CoA dehydrogenase, conserved site
      IPR036250 Acyl-CoA dehydrogenase-like, C-terminal
      IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
      IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
      IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
      IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
      IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
    Molecular
    Reagents
    less
    • All nucleic 123
      Genomic 2
      cDNA 118
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1025, MGD-MRK-1517, MGD-MRK-1518, MGI:2140816, MGI:2448341
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 9
      Phenotypes 30
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:237617 Menendez-Montes I, et al., Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation. Dev Cell. 2016 Dec 19;39(6):724-739

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory