Acads
Gene Detail

Symbol Name ID

Acads acyl-Coenzyme A dehydrogenase, short chain MGI:87868

Synonyms

Bcd1, Bcd-1, Hdlq8, SCAD

Feature Type

protein coding gene

Genetic Map

Chromosome 5

55.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)

Sequence Map

Chr5:115110299-115119346 bp, - strand From VEGA annotation of GRCm38   9048 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Acads ± 2 cM)

Gene Tree: Acads

Human ortholog

ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain NCBI Gene ID 35
Human Synonyms: ACAD3, SCAD
Human Chr12:121163571-121177811 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human ACADS (1)

Alleles and phenotypes

All alleles(9) : Targeted(2) Gene trapped(2) Spontaneous(1) QTL(2) Other(2)
 

Mice homozygous for disruptions in this gene display organic aciduria and develop hypoglycemia and fatty livers after fasting.

 
Human Diseases Modeled Using Mouse Acads (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	butyrate catabolic process, fatty acid beta-oxidation using acyl-CoA dehydrogenase, ...
Component	mitochondrial matrix, mitochondrial membrane, ...
Function	acyl-CoA dehydrogenase activity, butyryl-CoA dehydrogenase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (8)    Tissues (8)   
Theiler Stages: 28

Assay Type	Results
Northern blot	8

cDNA source data(117)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(122) Genomic(2) cDNA(117) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000014625 (Evidence)
Ensembl Gene Model	ENSMUSG00000029545 (Evidence)
Entrez Gene	11409 (Evidence)
UniGene	18759
DFCI	TC1576568, TC1771810
DoTS	DT.101127711, DT.534266, DT.97334603
NIA Mouse Gene Index	U026619
EC	1.3.8.1
Consensus CDS Project	CCDS19579.1
International Mouse Knockout Project Status	Acads

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014625	VEGA Gene Model | MGI Sequence Detail	9048	C57BL/6J
transcript	OTTMUST00000034682	VEGA | MGI Sequence Detail	1870	Not Applicable
polypeptide	OTTMUSP00000015526	VEGA | MGI Sequence Detail	412	Not Applicable

All sequences(37) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(16) : PCR(2) RFLP(14) SNPs(24 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006089	Acyl-CoA dehydrogenase, conserved site
InterPro	IPR006092	Acyl-CoA dehydrogenase, N-terminal
InterPro	IPR009100	Acyl-CoA dehydrogenase/oxidase
InterPro	IPR009075	Acyl-CoA dehydrogenase/oxidase C-terminal
InterPro	IPR013786	Acyl-CoA dehydrogenase/oxidase, N-terminal
InterPro	IPR006091	Acyl-CoA oxidase/dehydrogenase, central domain
InterPro	IPR006090	Acyl-CoA oxidase/dehydrogenase, type 1
Protein Ontology	PR:000003602	short-chain specific acyl-CoA dehydrogenase, mitochondrial

References

(Earliest) J:6531 Seeley TL, et al., Genetics and ontogeny of butyryl CoA dehydrogenase in the mouse and linkage of Bcd-1 with Dao-1. Biochem Genet. 1981 Apr;19(3-4):333-45
(Latest) J:191682 Kruger C, et al., Brain transcriptional responses to high-fat diet in Acads-deficient mice reveal energy sensing pathways. PLoS One. 2012;7(8):e41709
All references(72)

Other accession IDs

MGD-MRK-1025, MGD-MRK-1517, MGD-MRK-1518, MGI:2140816, MGI:2448341