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Acads
Gene Detail
Symbol

Name
ID
Acads
acyl-Coenzyme A dehydrogenase, short chain
MGI:87868
Synonyms
Bcd1, Bcd-1, Hdlq8, SCAD
Feature Type
protein coding gene
Genetic Map
Chromosome 5
55.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr5:115110299-115119346 bp, - strand
From VEGA annotation of GRCm38

  9048 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20057  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ACADS
Gene Tree: Acads

Human
homologs
ACADS, acyl-CoA dehydrogenase, C-2 to C-3 short chain
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 35
neXtProt AC: NX_P16219

Human Synonyms: ACAD3, SCAD

Human Chr (Location): 12q24.31; chr12:120725738-120740008 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ACADS

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) QTL(2) Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display organic aciduria and develop hypoglycemia and fatty livers after fasting.
 
Human Diseases Modeled in Mice Using Acads (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Acads interacts with 57 markers (Mir29a, Mir34b, Mir34c, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (8)    Tissues (8)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 8
cDNA source data(117)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase acads    NEW 
Molecular
reagents
All nucleic(122) Genomic(2) cDNA(117) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000014625 (Evidence)
Ensembl Gene Model ENSMUSG00000029545 (Evidence)
Entrez Gene 11409 (Evidence)
UniGene 18759
DFCI TC1576568, TC1771810
DoTS DT.101127711, DT.534266, DT.97334603
NIA Mouse Gene Index U026619
EC 1.3.8.1
Consensus CDS Project CCDS19579.1
International Mouse Phenotyping Consortium Status Acads
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014625 VEGA Gene Model | MGI Sequence Detail 9048 C57BL/6J ±  kb
transcript OTTMUST00000034682 VEGA | MGI Sequence Detail 1870 Not Applicable 
polypeptide OTTMUSP00000015526 VEGA | MGI Sequence Detail 412 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(16) : PCR(2) RFLP(14) SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006089 Acyl-CoA dehydrogenase, conserved site
InterPro IPR009100 Acyl-CoA dehydrogenase/oxidase
InterPro IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
InterPro IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
InterPro IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
Protein Ontology PR:000003602 short-chain specific acyl-CoA dehydrogenase, mitochondrial
References
(Earliest) J:6531 Seeley TL, et al., Genetics and ontogeny of butyryl CoA dehydrogenase in the mouse and linkage of Bcd-1 with Dao-1. Biochem Genet. 1981 Apr;19(3-4):333-45
(Latest) J:212122 Wang W, et al., Complex changes in the liver mitochondrial proteome of short chain acyl-CoA dehydrogenase deficient mice. Mol Genet Metab. 2014 May;112(1):30-9
All references(73)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1025, MGD-MRK-1517, MGD-MRK-1518, MGI:2140816, MGI:2448341

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory