About   Help   FAQ
Spontaneous Allele Detail
Symbol: Acadsdel-J
Name: acyl-Coenzyme A dehydrogenase, short chain; deletion, Jackson
MGI ID: MGI:3029768
Synonyms: Bcd-1c, Scad
Gene: Acads  Location: Chr5:115248358-115257405 bp, - strand  Genetic Position: Chr5, 55.99 cM
Alliance: Acadsdel-J page
Strain of Origin:  BALB/cByJ
Allele Type:    Spontaneous (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA 278bp deletion occurs which starts in intron "A" and includes exon "B" and the first 78bp of exon "C". As a result of this deletion, mRNA transcription is reduced to about 35% of normal and includes two forms, a longer normal length transcript and a shorter misspliced form. If these mRNAs were translated they both would result in truncated products. Protein product is undetectable immunologically and there is a total absence of enzyme activity. (J:12776, J:50729)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Acads Mutation:  14 strains or lines available
Original:  J:14707 Wood PA, et al., Short-chain acyl-coenzyme A dehydrogenase deficiency in mice. Pediatr Res. 1989 Jan;25(1):38-43
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory