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a
Gene Detail
Symbol

Name
ID
a
nonagouti
MGI:87853
Synonyms
agouti, agouti signal protein, As, ASP
Feature Type
protein coding gene
Genetic Map
Chromosome 2
76.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(298)
Sequence Map
Chr2:154791402-155051012 bp, + strand
From VEGA annotation of GRCm38

  259611 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: agouti-signaling protein/agouti-related protein
Gene Tree: a
Mutations,
alleles, and
phenotypes
All mutations/alleles(402) : Chemically and radiation induced(2) Chemically induced (ENU)(10) Chemically induced (other)(5) Gene trapped(296) Radiation induced(29) Spontaneous(58) Targeted(2)
Genomic Mutations involving a (1)
Incidental mutations (data from Mutagenetix , APF )
 
Agouti acts in the hair follicles, primarily affecting the relative amount and distribution of yellow pigment (phaeomelanin) and black pigment (eumelanin) in hairs of the coat. Some alleles show lethal effects or are associated with obesity.
 
Human Diseases Modeled Using Mouse a (2)    Alleles Annotated to Human Diseases(5)    Phenotype Images(11)
Interactions
a interacts with 19 markers (Mir29a, Mir103-2, Mir107, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process adult feeding behavior, generation of precursor metabolites and energy, ...
Component cell, extracellular region
Function melanocortin receptor binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (35)    Tissues (9)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
Northern blot 10
RT-PCR 23
cDNA source data(15)
External Resources: Expression Atlas
Molecular
reagents
All nucleic(63) Genomic(43) cDNA(15) Primer pair(2) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015981 (Evidence)
Ensembl Gene ModelENSMUSG00000027596 (Evidence)
Entrez Gene102635816, 50518
DFCITC1601603, TC1594947
DoTSDT.101229252, DT.110664312, DT.40186134, DT.91410771, DT.94384564
Consensus CDS ProjectCCDS16941.1
International Mouse Knockout Project Statusa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015981 VEGA Gene Model | MGI Sequence Detail 259611 C57BL/6J ±  kb
transcript OTTMUST00000038037 VEGA | MGI Sequence Detail 731 Not Applicable 
polypeptide OTTMUSP00000017061 VEGA | MGI Sequence Detail 131 Not Applicable 

For the selected sequences
All sequences(44) UniProt(5)
Polymorphisms
RFLP(10) : SNPs within 2kb(1994 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2062)
Protein-related
information
ResourceIDDescription
InterPro IPR007733 Agouti
InterPro IPR027300 Agouti domain
Protein Ontology PR:000004372 agouti-signaling protein
References
(Earliest) J:15011 Dunn LC, A Fifth Allelomorph in the Agouti Series of the House Mouse. Proc Natl Acad Sci U S A. 1928 Oct;14(10):816-9
(Latest) J:213411 Zevnik B, et al., C57BL/6N albino/agouti mutant mice as embryo donors for efficient germline transmission of C57BL/6 ES cells. PLoS One. 2014;9(3):e90570
All references(568)
Disease annotation references (8)
Other
accession IDs
MGD-MRK-1002, MGD-MRK-1008, MGD-MRK-1397

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory