a
Gene Detail

Symbol Name ID

a nonagouti MGI:87853

Synonyms

agouti, agouti signal protein, As, ASP

Feature Type

protein coding gene

Genetic Map

Chromosome 2

76.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(298)

Sequence Map

Chr2:154791402-155051012 bp, + strand From VEGA annotation of GRCm38   259611 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1264  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: agouti-signaling protein/agouti-related protein
Gene Tree: a

Human homologs

Human Homolog		ASIP, agouti signaling protein
NCBI Gene ID		434
neXtProt AC		NX_P42127
Human Synonyms		AGSW, AGTI, AGTIL, ASP, SHEP9
Human Chr (Location)		20q11.2-q12; chr20:32848171-32857148 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ASIP

Alleles and phenotypes

All alleles(401) : Targeted(1) Gene trapped(296) Spontaneous(58) Chemically induced(16) Radiation induced(30) Other(1)
 

Agouti acts in the hair follicles, primarily affecting the relative amount and distribution of yellow pigment (phaeomelanin) and black pigment (eumelanin) in hairs of the coat. Some alleles show lethal effects or are associated with obesity.

 
Human Diseases Modeled Using Mouse a (2)    Alleles Annotated to Human Diseases(5)    Phenotype Images(11)

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	adult feeding behavior, generation of precursor metabolites and energy, ...
Component	extracellular region
Function	melanocortin receptor binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (37)    Tissues (9)    Images (5)
Theiler Stages: 4, 28

Assay Type	Results
RNA in situ	2
Northern blot	10
RT-PCR	25

cDNA source data(16)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(64) Genomic(43) cDNA(16) Primer pair(2) Other(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000015981 (Evidence)
Ensembl Gene Model	ENSMUSG00000027596 (Evidence)
Entrez Gene	50518 (Evidence)
DFCI	TC1594947, TC1601603
DoTS	DT.101229252, DT.110664312, DT.40186134, DT.91410771, DT.94228288, DT.94384564
Consensus CDS Project	CCDS16941.1
International Mouse Knockout Project Status	a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015981	VEGA Gene Model | MGI Sequence Detail	259611	C57BL/6J
transcript	OTTMUST00000038104	VEGA | MGI Sequence Detail	705	Not Applicable
polypeptide	OTTMUSP00000017084	VEGA | MGI Sequence Detail	131	Not Applicable

All sequences(53) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(10) : SNPs(103 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007733	Agouti
Protein Ontology	PR:000004372	agouti-signaling protein

References

(Earliest) J:15011 Dunn LC, A Fifth Allelomorph in the Agouti Series of the House Mouse. Proc Natl Acad Sci U S A. 1928 Oct;14(10):816-9
(Latest) J:193279 Rosenfeld CS, et al., Maternal exposure to bisphenol A and genistein has minimal effect on A(vy)/a offspring coat color but favors birth of agouti over nonagouti mice. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):537-42
All references(550)

Other accession IDs

MGD-MRK-1002, MGD-MRK-1008, MGD-MRK-1397