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a Gene Detail
Summary
  • Symbol
    a
  • Name
    nonagouti
  • Synonyms
    agouti, agouti signal protein, As, ASP
  • Feature Type
    protein coding gene
  • IDs
    MGI:87853
    NCBI Gene: 50518
  • Gene Overview
    MyGene.info: ASIP
Location & Maps
more
  • Sequence Map
    Chr2:154791402-155051012 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      259611 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 76.83 cM
  • Mapping Data
    299 experiments
Homology
more
  • Human Ortholog
    ASIP, agouti signaling protein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ASIP, agouti signaling protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AGSW, AGTI, AGTIL, ASP, SHEP9
  • Links
    NCBI Gene ID: 434
    neXtProt AC: NX_P42127

  • Chr Location
    20q11.2-q12; chr20:34186493-34269344 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with a mouse models

Human Disease Mouse Models
       Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853 View 1 model
Obesity   OMIM: 601665 View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    62 phenotypes from 85 alleles in 42 genetic backgrounds
    124 phenotypes from multigenic genotypes
    11 images
    366 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    405
  • Chemically and radiation induced
    2
  • Chemically induced (ENU)
    10
  • Chemically induced (other)
    5
  • Gene trapped
    296
  • Radiation induced
    29
  • Spontaneous
    58
  • Targeted
    2
  • Transgenic
    3
  • Genomic Mutations
    1 involving a
  • Incidental Mutations
Agouti acts in the hair follicles, primarily affecting the relative amount and distribution of yellow pigment (phaeomelanin) and black pigment (eumelanin) in hairs of the coat. Some alleles show lethal effects or are associated with obesity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015981 VEGA Gene Model | MGI Sequence Detail 259611 C57BL/6J ±  kb
transcript OTTMUST00000038104 VEGA | MGI Sequence Detail 705 Not Applicable  
polypeptide OTTMUSP00000017084 VEGA | MGI Sequence Detail 131 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1942 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 64
    Genomic 43
    cDNA 16
    Primer pair 2
    Other 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1002, MGD-MRK-1008, MGD-MRK-1397
References
more
  • Summaries
    All 579
    Developmental Gene Expression 7
    Diseases 12
    Gene Ontology 8
    Phenotypes 366
  • Earliest
    J:15011 Dunn LC, A Fifth Allelomorph in the Agouti Series of the House Mouse. Proc Natl Acad Sci U S A. 1928 Oct;14(10):816-9
  • Latest
    J:222870 Liu ZQ, et al., Fumosorinone, a novel PTP1B inhibitor, activates insulin signaling in insulin-resistance HepG2 cells and shows anti-diabetic effect in diabetic KKAy mice. Toxicol Appl Pharmacol. 2015 May 15;285(1):61-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory