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a
Gene Detail
 Symbol
Name
ID
a
nonagouti
MGI:87853
Synonyms agouti, agouti signal protein, As, ASP
Feature Type protein coding gene
Genetic Map
Chromosome 2
76.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(298)
Sequence Map
Chr2:154791402-155051012 bp, + strand
From VEGA annotation of GRCm38

  259611 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1264  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: agouti-signaling protein/agouti-related protein
Gene Tree: a

Human
homologs
Human Homolog ASIP, agouti signaling protein
NCBI Gene ID 434
neXtProt AC  NX_P42127
Human Synonyms  AGSW, AGTI, AGTIL, ASP, SHEP9
Human Chr (Location)  20q11.2-q12; chr20:34241382-34269344 (+)  GRCh38
Alleles
and
phenotypes
All alleles(401) : Chemically and radiation induced(1) Chemically induced (ENU)(10) Chemically induced (other)(5) Gene trapped(296) Radiation induced(29) Spontaneous(58) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Agouti acts in the hair follicles, primarily affecting the relative amount and distribution of yellow pigment (phaeomelanin) and black pigment (eumelanin) in hairs of the coat. Some alleles show lethal effects or are associated with obesity.
 
Human Diseases Modeled Using Mouse a (2)    Alleles Annotated to Human Diseases(5)    Phenotype Images(11)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process adult feeding behavior, generation of precursor metabolites and energy, ...
Component cell, extracellular region
Function melanocortin receptor binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (37)    Tissues (9)    Images (5)
Theiler Stages: 4, 28
Assay TypeResults
RNA in situ 2
Northern blot 10
RT-PCR 25
cDNA source data(16)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(64) Genomic(43) cDNA(16) Primer pair(2) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015981 (Evidence)
Ensembl Gene ModelENSMUSG00000027596 (Evidence)
Entrez Gene50518 (Evidence)
DFCITC1594947, TC1601603
DoTSDT.101229252, DT.110664312, DT.40186134, DT.91410771, DT.94228288, DT.94384564
Consensus CDS ProjectCCDS16941.1
International Mouse Knockout Project Statusa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015981 VEGA Gene Model | MGI Sequence Detail 259611 C57BL/6J ±  kb
transcript OTTMUST00000038104 VEGA | MGI Sequence Detail 705 Not Applicable 
polypeptide OTTMUSP00000017084 VEGA | MGI Sequence Detail 131 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(4) UniProt(3)
Polymorphisms RFLP(10) : SNPs within 2kb(1994 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2062)
Protein-related
information
ResourceIDDescription
InterPro IPR007733 Agouti
InterPro IPR027300 Agouti domain
Protein Ontology PR:000004372 agouti-signaling protein
References (Earliest) J:15011 Dunn LC, A Fifth Allelomorph in the Agouti Series of the House Mouse. Proc Natl Acad Sci U S A. 1928 Oct;14(10):816-9
(Latest) J:209014 Marino A, et al., ITCH deficiency protects from diet-induced obesity. Diabetes. 2014 Feb;63(2):550-61
All references(565)
Other
accession IDs
MGD-MRK-1002, MGD-MRK-1008, MGD-MRK-1397

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory