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a Gene Detail
Summary
  • Symbol
    a
  • Name
    nonagouti
  • Synonyms
    agouti, agouti signal protein, As, ASP
  • Feature Type
    protein coding gene
  • IDs
    MGI:87853
    NCBI Gene: 50518
  • Gene Overview
    MyGene.info: ASIP
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:154791402-155051012 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      259611 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 76.83 cM
  • Mapping Data
    299 experiments
Homology
more
  • Human Ortholog
    ASIP, agouti signaling protein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ASIP, agouti signaling protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AGSW, AGTI, AGTIL, ASP, SHEP9
  • Links
    NCBI Gene ID: 434
    neXtProt AC: NX_P42127
    UniProt: P42127

  • Chr Location
    20q11.22; chr20:34186493-34269344 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with a mouse models

Human Disease Mouse Models
      
IDs
View 4 models
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    9 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    62 phenotypes from 85 alleles in 46 genetic backgrounds
    125 phenotypes from multigenic genotypes
    11 images
    378 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Agouti acts in the hair follicles, primarily affecting the relative amount and distribution of yellow pigment (phaeomelanin) and black pigment (eumelanin) in hairs of the coat. Some alleles show lethal effects or are associated with obesity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000015981 VEGA Gene Model | MGI Sequence Detail 259611 C57BL/6J ±  kb
    transcript OTTMUST00000038104 VEGA | MGI Sequence Detail 705 Not Applicable  
    polypeptide OTTMUSP00000017084 VEGA | MGI Sequence Detail 131 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1942 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 63
      Genomic 43
      cDNA 15
      Primer pair 2
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1002, MGD-MRK-1008, MGD-MRK-1397
    References
    more
    • Summaries
      All 599
      Developmental Gene Expression 7
      Diseases 9
      Gene Ontology 9
      Phenotypes 378
    • Earliest
      J:15011 Dunn LC, A Fifth Allelomorph in the Agouti Series of the House Mouse. Proc Natl Acad Sci U S A. 1928 Oct;14(10):816-9
    • Latest
      J:258438 Sasso O, et al., The N-Acylethanolamine Acid Amidase Inhibitor ARN077 Suppresses Inflammation and Pruritus in a Mouse Model of Allergic Dermatitis. J Invest Dermatol. 2018 Mar;138(3):562-569

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory