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Drc1
Gene Detail
 Symbol
Name
ID
Drc1
dynein regulatory complex subunit 1
MGI:2685906
Synonyms b2b1654Clo, Ccdc164, Gm1060, LOC381738
Feature Type protein coding gene
Genetic Map
Chromosome 5
16.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:30341663-30366708 bp, + strand
From NCBI annotation of GRCm38

  25046 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:35977  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Drc1

Human
homologs
Human Homolog DRC1, dynein regulatory complex subunit 1
NCBI Gene ID 92749
neXtProt AC  NX_Q96MC2
Human Synonyms  C2orf39, CCDC164, CILD21
Human Chr (Location)  2p23.3; chr2:26401916-26456711 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DRC1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(2) Radiation induced(3)
Genomic Mutations involving Drc1 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for ENU-induced mutations exhibit heterotaxy with complex congenital heart disease such as transposition of the great arteries (TGA), atrioventricular septal defects (AVSD), and vein abnormalities; immotile/dyskinetic airway cilia are also seen.
 
Human Diseases Modeled Using Mouse Drc1 (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(21)
Interactions
Drc1 interacts with 42 markers (Mir96, Mir136, Mir149, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process axonemal dynein complex assembly, bacterial-type flagellum-dependent cell motility, ...
Component cell projection, cilium, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (37)    Tissues (5)    Images (19)
Theiler Stages: 23
Assay TypeResults
RNA in situ 37
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(3) cDNA(3)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000073102 (Evidence)
Entrez Gene381738 (Evidence)
DFCITC1583987
DoTSDT.111111695, DT.482196
NIA Mouse Gene IndexU005416
International Mouse Knockout Project StatusDrc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 381738 NCBI Gene Model | MGI Sequence Detail 25046 C57BL/6J ±  kb
transcript NM_001033460 RefSeq | MGI Sequence Detail 2485 C57BL/6 
polypeptide Q3USS3 UniProt | EBI | MGI Sequence Detail 753 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000031828 coiled-coil domain-containing protein 164
Graphical View of Protein Domain Structure
References (Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(21)
Disease annotation references (1)
Other
accession IDs
MGI:5438047

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory