Dnaic1
Gene Detail

Symbol Name ID

Dnaic1 dynein, axonemal, intermediate chain 1 MGI:1916172

Synonyms

1110066F04Rik, b2b1526Clo

Feature Type

protein coding gene

Genetic Map

Chromosome 4

21.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:41569775-41638158 bp, + strand From VEGA annotation of GRCm38   68384 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8122  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dnaic1

Human homologs

Human Homolog		DNAI1, dynein, axonemal, intermediate chain 1
NCBI Gene ID		27019
neXtProt AC		NX_Q9UI46
Human Synonyms		CILD1, DIC1, ICS, ICS1, PCD
Human Chr (Location)		9p13.3; chr9:34458811-34520982 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DNAI1

Alleles and phenotypes

All alleles(8) : Targeted(4) Gene trapped(2) Chemically induced(2)
 

Mutant mice exhibit situs inversus, heterotaxia and ciliary dyskinesia including cardiovascular defects and decreased ciliary activity in the trachea, reduced to absent mucociliary clearance, and chronic rhinosinusitis. Hydrocephaly is also seen.

 
Human Diseases Modeled Using Mouse Dnaic1 (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(22)

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	epithelial cilium movement
Component	cell projection, cilium, ...
Function	motor activity

External Resources: FuncBase

Expression

Literature Summary: (2 records)
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(7)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000006654 (Evidence)
Ensembl Gene Model	ENSMUSG00000061322 (Evidence)
Entrez Gene	68922 (Evidence)
UniGene	79127
DFCI	TC1584344, TC1643898
DoTS	DT.101168890, DT.55274746, DT.91576000
NIA Mouse Gene Index	U004216
Consensus CDS Project	CCDS18066.1
International Mouse Knockout Project Status	Dnaic1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006654	VEGA Gene Model | MGI Sequence Detail	68384	C57BL/6J
transcript	OTTMUST00000015206	VEGA | MGI Sequence Detail	2510	Not Applicable
polypeptide	OTTMUSP00000007027	VEGA | MGI Sequence Detail	701	Not Applicable

All sequences(33) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(265 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR017986	WD40-repeat-containing domain
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000006568	dynein intermediate chain 1, axonemal

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:186572 Francis RJ, et al., Congenital heart disease and the specification of left-right asymmetry. Am J Physiol Heart Circ Physiol. 2012 May 15;302(10):H2102-11
All references(35)

Other accession IDs

MGI:2140635, MGI:5317586