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n-TUtca2 Gene Detail
Summary
  • Symbol
    n-TUtca2
  • Name
    nuclear encoded tRNA selenocysteine 2 (anticodon TCA)
  • Synonyms
    opal suppressor, selenocysteine tRNA, trna86-SeC(e)TCA, tRNA Sec, Trnau1, Trsp
  • Feature Type
    tRNA gene
  • IDs
    MGI:4414022
    NCBI Gene: 22069
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:19301244-19301329 bp, + strand
  • From GtRNAdb annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      86 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.56 cM
  • Mapping Data
    5 experiments
Human Diseases
more
  • Diseases
    1 with n-TUtca2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 6 alleles in 7 genetic backgrounds
    10 phenotypes from multigenic genotypes
    6 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for mutations that inactivate the gene die shortly after implantation. Selective disruption of the gene in mammary epithial tissue did not impair lactation or mammary development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Literature Summary
  • Other Mouse Links
Sequences &
Gene Models
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  • All Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic D43641 GenBank | EMBL | DDBJ | MGI Sequence Detail 3821 129/Sv ±  kb
transcript L14949 GenBank | EMBL | DDBJ | MGI Sequence Detail 90 Not Specified  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    30 from dbSNP Build 142
  • RFLP
Molecular
Reagents
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  • All nucleic 4
    Genomic 2
    cDNA 1
    Other 1
Other
Accession IDs
less
MGD-MRK-15251, MGI:98837
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 7
    Phenotypes 20
  • Earliest
    J:1449 Mizutani T, et al., Some properties of murine selenocysteine synthase [published erratum appears in Biochem J 1992 Dec 15;288(Pt 3):1077]. Biochem J. 1992 Jun 15;284(Pt 3):827-34
  • Latest
    J:229123 Parsons TE, et al., Mind the gap: genetic manipulation of basicranial growth within synchondroses modulates calvarial and facial shape in mice through epigenetic interactions. PLoS One. 2015;10(2):e0118355

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/16/2018
MGI 6.11
The Jackson Laboratory