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Xaf1
Gene Detail
Symbol

Name
ID
Xaf1
XIAP associated factor 1
MGI:3772572
Feature Type
protein coding gene
Genetic Map
Chromosome 11
43.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:72301629-72313733 bp, + strand
From VEGA annotation of GRCm38

  12105 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49488  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

HCOP human homology predictions: XAF1
Gene Tree: Xaf1

Human
homologs
XAF1, XIAP associated factor 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 54739
neXtProt AC: NX_Q6GPH4

Human Synonyms: BIRC4BP, HSXIAPAF1, XIAPAF1

Human Chr (Location): 17p13.1; chr17:6755572-6775647 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Genomic Mutations involving Xaf1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Xaf1 interacts with 283 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process apoptotic process, negative regulation of protein complex assembly, ...
Component cytoplasm, mitochondrion, ...
Function metal ion binding
Expression
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000006106 (Evidence)
Ensembl Gene Model ENSMUSG00000040483 (Evidence)
Entrez Gene 327959 (Evidence)
UniGene 291131
DFCI TC1667977, TC1624897, TC1676840, TC1587522, TC1687442
DoTS DT.101237489, DT.55272698, DT.91322501, DT.40138320, DT.40134578
NIA Mouse Gene Index U012878
Consensus CDS Project CCDS24984.2, CCDS70236.1
International Mouse Phenotyping Consortium Status Xaf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006106 VEGA Gene Model | MGI Sequence Detail 12105 C57BL/6J ±  kb
transcript OTTMUST00000013799 VEGA | MGI Sequence Detail 2597 Not Applicable 
polypeptide OTTMUSP00000006397 VEGA | MGI Sequence Detail 273 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(16) UniProt(3)
Polymorphisms
SNPs within 2kb(126 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000017471 XIAP-associated factor 1
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:91241 Wang X, et al., X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia. Neurobiol Dis. 2004 Jun;16(1):179-89
All references(23)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory