Xaf1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Xaf1
XIAP associated factor 1
MGI:3772572

19 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Xaf1^em1(IMPC)Mbp/Xaf1^em1(IMPC)Mbp C57BL/6N-Xaf1^em1(IMPC)Mbp/MbpMmucd	abnormal caudal vertebrae morphology	J:211773
	abnormal skin morphology	J:211773
	abnormal stomach morphology	J:211773
	enlarged stomach	J:211773
Xaf1^em1Gaod/Xaf1^em1Gaod involves: C57BL/6	decreased circulating glucose level	J:338549
	decreased circulating insulin level	J:338549
	decreased energy expenditure	J:338549
	decreased susceptibility to diet-induced obesity	J:338549
	improved glucose tolerance	J:338549
	increased insulin sensitivity	J:338549
	increased oxygen consumption	J:338549
Xaf1^em2.1Cya/Xaf1^em2.1Cya C57BL/6J-Xaf1^em2.1Cya	abnormal circulating protein level	J:344340
	abnormal tumor necrosis factor level	J:344340
	decreased circulating CXCL10 level	J:344340
	decreased circulating interferon-beta level	J:344340
	decreased macrophage cytokine production	J:344340
	normal immune system phenotype	J:344340
	increased susceptibility to Riboviria infection	J:344340
	increased susceptibility to Riboviria infection induced morbidity/mortality	J:344340

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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