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Xaf1 Gene Detail
Summary
  • Symbol
    Xaf1
  • Name
    XIAP associated factor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3772572
    NCBI Gene: 327959
Location & Maps
more
  • Sequence Map
    Chr11:72301629-72313733 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12105 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 43.99 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    XAF1, XIAP associated factor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    XAF1, XIAP associated factor 1
    Orthology source: HomoloGene
  • Synonyms
    BIRC4BP, HSXIAPAF1, XIAPAF1
  • Links
    NCBI Gene ID: 54739
    neXtProt AC: NX_Q6GPH4

  • Chr Location
    17p13.1; chr17:6755572-6775647 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Xaf1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006106 VEGA Gene Model | MGI Sequence Detail 12105 C57BL/6J ±  kb
transcript OTTMUST00000013799 VEGA | MGI Sequence Detail 2597 Not Applicable  
polypeptide OTTMUSP00000006397 VEGA | MGI Sequence Detail 273 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    126 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000017471 XIAP-associated factor 1
  • InterPro Domains
    IPR031220 XIAP-associated factor 1
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 2
References
more
  • Summaries
    All 21
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:91241 Wang X, et al., X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia. Neurobiol Dis. 2004 Jun;16(1):179-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory