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Xaf1 Gene Detail
Summary
  • Symbol
    Xaf1
  • Name
    XIAP associated factor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3772572
    NCBI Gene: 327959
  • Gene Overview
    MyGene.info: XAF1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:72301629-72313733 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 43.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    126 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3772572
protein coding gene Chr11:72301432-72313733 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018635
protein coding gene Chr11:72920353-72932522 (+)
A/J MGP_AJ_G0018603
protein coding gene Chr11:70193263-70208880 (+)
AKR/J MGP_AKRJ_G0018572
protein coding gene Chr11:72338239-72350340 (+)
BALB/cJ MGP_BALBcJ_G0018575
protein coding gene Chr11:70489228-70503695 (+)
C3H/HeJ MGP_C3HHeJ_G0018388
protein coding gene Chr11:72289105-72302247 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019026
protein coding gene Chr11:75129864-75144225 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016669
protein coding gene Chr11:67033025-67044833 (+)
CAST/EiJ MGP_CASTEiJ_G0017943
protein coding gene Chr11:72663960-72677319 (+)
CBA/J MGP_CBAJ_G0018360
protein coding gene Chr11:78454943-78466978 (+)
DBA/2J MGP_DBA2J_G0018469
protein coding gene Chr11:69834190-69845989 (+)
FVB/NJ MGP_FVBNJ_G0018460
protein coding gene Chr11:69366476-69378508 (+)
LP/J MGP_LPJ_G0018540
protein coding gene Chr11:73426144-73439127 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018483
protein coding gene Chr11:79021335-79035179 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019068
protein coding gene Chr11:72536447-72548546 (+)
PWK/PhJ MGP_PWKPhJ_G0017716
protein coding gene Chr11:70450344-70462163 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017506
protein coding gene Chr11:72233489-72245716 (+)
WSB/EiJ MGP_WSBEiJ_G0017997
protein coding gene Chr11:72270023-72283080 (+)



Homology
more
  • Human Ortholog
    XAF1, XIAP associated factor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    XAF1, XIAP associated factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BIRC4BP, HSXIAPAF1, XIAPAF1
  • Links
    NCBI Gene ID: 54739
    neXtProt AC: NX_Q6GPH4
    UniProt: Q6GPH4

  • Chr Location
    17p13.1; chr17:6755411-6775647 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040483 Ensembl Gene Model | MGI Sequence Detail 12105 C57BL/6J ±  kb
transcript ENSMUST00000146233 Ensembl | MGI Sequence Detail 2597 Not Applicable  
polypeptide ENSMUSP00000123011 Ensembl | MGI Sequence Detail 273 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 2
References
more
  • Summaries
    All 29
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:174216 Terzian T, et al., Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug;224(4):540-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory