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Cyp3a59 Gene Detail
Summary
  • Symbol
    Cyp3a59
  • Name
    cytochrome P450, family 3, subfamily a, polypeptide 59
  • Feature Type
    protein coding gene
  • IDs
    MGI:3769707
    NCBI Gene: 100041449
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:146016067-146050097 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 85.17 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    246 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3769707
 protein coding gene Chr5:146016018-146051788 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030373
 protein coding gene Chr5:151490933-151531535 (-)
A/J MGP_AJ_G0030341
 protein coding gene Chr5:145104249-145216847 (+)
AKR/J MGP_AKRJ_G0030267
 protein coding gene Chr5:148807358-149667607 (+)
BALB/cJ MGP_BALBcJ_G0030354
 protein coding gene Chr5:146220768-146294309 (-)
C3H/HeJ MGP_C3HHeJ_G0030068
 protein coding gene Chr5:150528123-150597050 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030802
 protein coding gene Chr5:157026500-157049800 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0030038
 protein coding gene Chr5:163499571-163571575 (-)
DBA/2J MGP_DBA2J_G0030183
 protein coding gene Chr5:144012022-144918519 (+)
FVB/NJ MGP_FVBNJ_G0030143
 protein coding gene Chr5:144079931-144114550 (+)
LP/J MGP_LPJ_G0030276
 protein coding gene Chr5:152129224-152222862 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030175
 protein coding gene Chr5:166002542-166062474 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030837
 protein coding gene Chr5:148730345-149559973 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0029019
 protein coding gene Chr5:146827749-146869355 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CYP3A43, cytochrome P450 family 3 subfamily A member 43
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP3A43, cytochrome P450 family 3 subfamily A member 43
  • Links
    NCBI Gene ID: 64816
    neXtProt AC: NX_Q9HB55
    UniProt: Q9HB55

  • Chr Location
    7q22.1; chr7:99828013-99866093 (+)  GRCh38
  • Human Ortholog
    CYP3A7, cytochrome P450 family 3 subfamily A member 7
  • Synonyms
    CP37, CYPIIIA7, P-450111A7, P-450(HFL33), P450-HFLA, P450HLp2
  • Links
    NCBI Gene ID: 1551
    neXtProt AC: NX_P24462
    UniProt: P24462

  • Chr Location
    7q22.1; chr7:99705036-99735196 (-)  GRCh38
  • Human Ortholog
    CYP3A7-CYP3A51P, CYP3A7-CYP3A51P readthrough
  • Synonyms
    CYP3A7, CYP3A7.1L, CYP3A7-3AP1, CYP3A7-CYP3AP1, CYPIIIA7
  • Links
    NCBI Gene ID: 100861540
    neXtProt AC: NX_P24462

  • Chr Location
    7q22.1; chr7:99684677-99735196 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human CYP3A4,CYP3A5 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061292 Ensembl Gene Model | MGI Sequence Detail 34031 C57BL/6J ±  kb
transcript ENSMUST00000035571 Ensembl | MGI Sequence Detail 1990 Not Applicable  
polypeptide ENSMUSP00000049494 Ensembl | MGI Sequence Detail 503 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 1
    cDNA 1
Other
Accession IDs
less
MGI:3642214
References
more
  • Summaries
    All 30
    Gene Ontology 3
    Phenotypes 21
  • Earliest
    J:127366 van Herwaarden AE, et al., Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism. J Clin Invest. 2007 Nov;117(11):3583-92
  • Latest
    J:345093 Heintz MM, et al., Human CYP2B6 produces oxylipins from polyunsaturated fatty acids and reduces diet-induced obesity. PLoS One. 2022;17(12):e0277053
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory