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Fancf Gene Detail
Summary
  • Symbol
    Fancf
  • Name
    Fanconi anemia, complementation group F
  • Feature Type
    protein coding gene
  • IDs
    MGI:3689889
    NCBI Gene: 100040608
  • Gene Overview
    MyGene.info: FANCF
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:51860577-51862267 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 32.87 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    21 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3689889
protein coding gene Chr7:51860577-51862267 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032306
protein coding gene Chr7:52626026-52627716 (-)
A/J MGP_AJ_G0032285
protein coding gene Chr7:51793119-51794809 (-)
AKR/J MGP_AKRJ_G0032221
protein coding gene Chr7:53010336-53012026 (-)
BALB/cJ MGP_BALBcJ_G0032297
protein coding gene Chr7:51443430-51445120 (-)
C3H/HeJ MGP_C3HHeJ_G0032010
protein coding gene Chr7:53413779-53415469 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032790
protein coding gene Chr7:54993923-54995613 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029797
protein coding gene Chr7:54809637-54811357 (-)
CAST/EiJ MGP_CASTEiJ_G0031339
protein coding gene Chr7:44736247-44738690 (-)
CBA/J MGP_CBAJ_G0031975
protein coding gene Chr7:56852869-56854559 (-)
DBA/2J MGP_DBA2J_G0032132
protein coding gene Chr7:50972814-50974504 (-)
FVB/NJ MGP_FVBNJ_G0032086
protein coding gene Chr7:50898145-50899835 (-)
LP/J MGP_LPJ_G0032213
protein coding gene Chr7:53575671-53577361 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032123
protein coding gene Chr7:55960070-55961760 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032807
protein coding gene Chr7:51989028-51990718 (-)
PWK/PhJ MGP_PWKPhJ_G0031059
protein coding gene Chr7:44277182-44279311 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030900
protein coding gene Chr7:40146520-40148196 (-)
WSB/EiJ MGP_WSBEiJ_G0031457
protein coding gene Chr7:52691028-52692718 (-)



Homology
more
  • Human Ortholog
    FANCF, FA complementation group F
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FANCF, FA complementation group F
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FAF
  • Links
    NCBI Gene ID: 2188
    neXtProt AC: NX_Q9NPI8
    UniProt: Q9NPI8

  • Chr Location
    11p14.3; chr11:22622533-22625841 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 75185
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FANCF
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Fancf mouse models; 1 with human FANCF associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 100040608 NCBI Gene Model | MGI Sequence Detail 1691 C57BL/6J ±  kb
transcript NM_001115087 RefSeq | MGI Sequence Detail 1691 C57BL/6  
polypeptide E9Q5Z5 UniProt | EBI | MGI Sequence Detail 343 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 4
References
more
  • Summaries
    All 20
    Diseases 1
    Gene Ontology 6
    Phenotypes 1
  • Earliest
    J:156320 Saberwal G, et al., The interferon consensus sequence binding protein (ICSBP/IRF8) activates transcription of the FANCF gene during myeloid differentiation. J Biol Chem. 2009 Nov 27;284(48):33242-54
  • Latest
    J:180025 Bakker ST, et al., Fancf-deficient mice are prone to develop ovarian tumours. J Pathol. 2012 Jan;226(1):28-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory