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Fancf Gene Detail
Summary
  • Symbol
    Fancf
  • Name
    Fanconi anemia, complementation group F
  • Feature Type
    protein coding gene
  • IDs
    MGI:3689889
    NCBI Gene: 100040608
  • Gene Overview
    MyGene.info: FANCF
Location & Maps
more
  • Sequence Map
    Chr7:51860577-51862267 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1691 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 32.87 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    FANCF, Fanconi anemia complementation group F
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FANCF, Fanconi anemia complementation group F
    Orthology source: HomoloGene
  • Synonyms
    FAF
  • Links
    NCBI Gene ID: 2188
    neXtProt AC: NX_Q9NPI8

  • Chr Location
    11p15; chr11:22622533-22625841 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 75185
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: FANCF
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human FANCF associations

Human Disease Mouse Models
       Fanconi Anemia, Complementation Group F; FANCF   OMIM: 603467
Tracheoesophageal Fistula with or without Esophageal Atresia   OMIM: 189960
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000059027 VEGA Gene Model | MGI Sequence Detail 1691 C57BL/6J ±  kb
transcript OTTMUST00000144804 VEGA | MGI Sequence Detail 1691 Not Applicable  
polypeptide OTTMUSP00000075439 VEGA | MGI Sequence Detail 343 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    21 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR025825 Fanconi anemia group F protein
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 4
References
more
  • Summaries
    All 16
    Gene Ontology 3
  • Earliest
    J:180025 Bakker ST, et al., Fancf-deficient mice are prone to develop ovarian tumours. J Pathol. 2012 Jan;226(1):28-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory