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Dnmt3c Gene Detail
Summary
  • Symbol
    Dnmt3c
  • Name
    DNA methyltransferase 3C
  • Synonyms
    Dnmt3c-ps, Gm14490
Location &
Maps
more
  • Sequence Map
    Chr2:153706484-153730013 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 75.87 cM
Strain
Comparison
more
  • SNPs within 2kb
    277 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3649996
protein coding gene Chr2:153696652-153730013 (+)
129S1/SvImJ MGP_129S1SvImJ_G0040280
pseudogene Chr2:158372771-158417887 (+)
A/J MGP_AJ_G0040262
pseudogene Chr2:152016279-152052320 (+)
AKR/J MGP_AKRJ_G0040196
pseudogene Chr2:156468630-156512885 (+)
BALB/cJ MGP_BALBcJ_G0040261
pseudogene Chr2:152325797-152377944 (+)
C3H/HeJ MGP_C3HHeJ_G0039896
pseudogene Chr2:156858159-156894693 (+)
C57BL/6NJ MGP_C57BL6NJ_G0040853
pseudogene Chr2:162979384-163034677 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0037284
pseudogene Chr2:145588138-145622576 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0039864
pseudogene Chr2:168995764-169039405 (+)
DBA/2J MGP_DBA2J_G0040062
pseudogene Chr2:151241431-151276888 (+)
FVB/NJ MGP_FVBNJ_G0040019
pseudogene Chr2:149694656-149727359 (+)
LP/J MGP_LPJ_G0040110
pseudogene Chr2:158505277-158547401 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0040015
pseudogene Chr2:172974903-173019274 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0040952
pseudogene Chr2:156376650-156413173 (+)
PWK/PhJ MGP_PWKPhJ_G0038676
pseudogene Chr2:150764095-150804941 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0039203
pseudogene Chr2:157269434-157313329 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 6 alleles in 3 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU or endonuclease-mediated mutation alleles exhibit reduced transposon and retrotransposons in male germ cells, male infertility, meiotic arrest, azoospermia and hypogonadism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    • UniProt
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 668932 NCBI Gene Model | MGI Sequence Detail 23530 C57BL/6J ±  kb
    polypeptide P0DOY1 UniProt | EBI | MGI Sequence Detail 740 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    References
    more
    • Summaries
      All 13
      Gene Ontology 4
      Phenotypes 3
    • Earliest
      J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
    • Latest
      J:244795 Jain D, et al., rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline. PLoS Genet. 2017 Aug;13(8):e1006964

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/30/2020
    MGI 6.15
    The Jackson Laboratory