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Dnmt3c Gene Detail
Summary
  • Symbol
    Dnmt3c
  • Name
    DNA methyltransferase 3C
  • Synonyms
    Dnmt3c-ps, Gm14490
Location & Maps
more
  • Sequence Map
    Chr2:153696652-153729905 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33254 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 75.87 cM
  • Mapping Data
    1 experiment
Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 6 alleles in 3 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU or endonuclease-mediated mutation alleles exhibit reduced transposon and retrotransposons in male germ cells, male infertility, meiotic arrest, azoospermia and hypogonadism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016816 VEGA Gene Model | MGI Sequence Detail 33254 C57BL/6J ±  kb
transcript OTTMUST00000040854 VEGA | MGI Sequence Detail 2218 Not Applicable  
polypeptide A0A286YDX7 UniProt | EBI | MGI Sequence Detail 740 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    416 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR025766 ADD domain
    IPR001525 C-5 cytosine methyltransferase
    IPR018117 DNA methylase, C-5 cytosine-specific, active site
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
    IPR011011 Zinc finger, FYVE/PHD-type
References
more
  • Summaries
    All 12
    Gene Ontology 1
    Phenotypes 4
  • Earliest
    J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
  • Latest
    J:244795 Jain D, et al., rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline. PLoS Genet. 2017 Aug;13(8):e1006964

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory