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Ifnl2 Gene Detail
Summary
  • Symbol
    Ifnl2
  • Name
    interferon lambda 2
  • Synonyms
    EG330496, Il28a
  • Feature Type
    protein coding gene
  • IDs
    MGI:3647279
    NCBI Gene: 330496
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr7:28508836-28510455 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 16.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    25 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3647279
protein coding gene Chr7:28508784-28510532 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031948
protein coding gene Chr7:27272568-27306332 (-)
A/J MGP_AJ_G0031927
protein coding gene Chr7:26656149-26657760 (+)
AKR/J MGP_AKRJ_G0031859
protein coding gene Chr7:27335961-27337581 (+)
BALB/cJ MGP_BALBcJ_G0031934
protein coding gene Chr7:26794531-26796142 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0032398
protein coding gene Chr7:28178889-28185229 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029450
protein coding gene Chr7:27674710-27708613 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0031619
protein coding gene Chr7:29473475-29475096 (+)
DBA/2J MGP_DBA2J_G0031772
protein coding gene Chr7:26413148-26414768 (+)
FVB/NJ MGP_FVBNJ_G0031729
protein coding gene Chr7:26485723-26487344 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0031764
protein coding gene Chr7:28948002-28949614 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032429
protein coding gene Chr7:26771860-26809568 (-)
PWK/PhJ MGP_PWKPhJ_G0030714
protein coding gene Chr7:21371137-21405599 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0031098
protein coding gene Chr7:27116251-27155824 (-)



Homology
more
  • Human Ortholog
    IFNL1, interferon lambda 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IFNL1, interferon lambda 1
    Orthology source: HGNC
  • Synonyms
    IL29, IL-29
  • Links
    NCBI Gene ID: 282618
    neXtProt AC: NX_Q8IU54
    UniProt: Q8IU54

  • Chr Location
    19q13.2; chr19:39296325-39298672 (+)  GRCh38.p7

  • Human Ortholog
    IFNL2, interferon lambda 2
    Orthology source: HGNC
  • Synonyms
    IL28A, IL-28A
  • Links
    NCBI Gene ID: 282616
    neXtProt AC: NX_Q8IZJ0
    UniProt: Q8IZJ0

  • Chr Location
    19q13.2; chr19:39268517-39270092 (+)  GRCh38.p7

  • Human Ortholog
    IFNL3, interferon lambda 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IFN-lambda-3, IFN-lambda-4, IL28B, IL-28B, IL28C, IL-28C
  • Links
    NCBI Gene ID: 282617
    neXtProt AC: NX_Q8IZI9
    UniProt: Q8IZI9

  • Chr Location
    19q13.2; chr19:39243536-39245481 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059128 Ensembl Gene Model | MGI Sequence Detail 1620 C57BL/6J ±  kb
transcript ENSMUST00000081684 Ensembl | MGI Sequence Detail 702 Not Applicable  
polypeptide ENSMUSP00000080384 Ensembl | MGI Sequence Detail 193 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR029177 Interferon lambda
    IPR038326 Interferon lambda superfamily
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 16
    Gene Ontology 5
  • Earliest
    J:172800 Pott J, et al., IFN-{lambda} determines the intestinal epithelial antiviral host defense. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7944-9
  • Latest
    J:260611 Hernandez PP, et al., Interferon-lambda and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection. Nat Immunol. 2015 Jul;16(7):698-707

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory