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Cyp3a57 Gene Detail
Summary
  • Symbol
    Cyp3a57
  • Name
    cytochrome P450, family 3, subfamily a, polypeptide 57
  • Synonyms
    EG622127
  • Feature Type
    protein coding gene
  • IDs
    MGI:3646373
    NCBI Gene: 622127
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:145282089-145327736 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 85.17 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    306 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3646373
 protein coding gene Chr5:145281959-145327736 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030366
 protein coding gene Chr5:150780774-150832097 (+)
A/J MGP_AJ_G0030335
 protein coding gene Chr5:144302051-144350853 (+)
AKR/J MGP_AKRJ_G0030268
 protein coding gene Chr5:148807368-148852829 (+)
BALB/cJ MGP_BALBcJ_G0030352
 protein coding gene Chr5:145569054-145620151 (+)
C3H/HeJ MGP_C3HHeJ_G0030063
 protein coding gene Chr5:149618472-149692316 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030797
 protein coding gene Chr5:156285177-156341450 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028018
 protein coding gene Chr5:138740521-138805226 (+)
CAST/EiJ MGP_CASTEiJ_G0029468
 protein coding gene Chr5:149196555-149276401 (+)
CBA/J MGP_CBAJ_G0030033
 protein coding gene Chr5:162735355-163686621 (+)
DBA/2J MGP_DBA2J_G0030184
 protein coding gene Chr5:144012022-144058233 (+)
FVB/NJ MGP_FVBNJ_G0030138
 protein coding gene Chr5:143260984-143309954 (+)
LP/J MGP_LPJ_G0030272
 protein coding gene Chr5:151373505-151446472 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030169
 protein coding gene Chr5:165049120-165098835 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030838
 protein coding gene Chr5:148730355-148776566 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0029021
 protein coding gene Chr5:146827751-146869355 (-)
WSB/EiJ MGP_WSBEiJ_G0029543
 protein coding gene Chr5:149517129-149564331 (+)



Homology
more
  • Human Ortholog
    CYP3A43, cytochrome P450 family 3 subfamily A member 43
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP3A43, cytochrome P450 family 3 subfamily A member 43
  • Links
    NCBI Gene ID: 64816
    neXtProt AC: NX_Q9HB55
    UniProt: Q9HB55

  • Chr Location
    7q22.1; chr7:99828013-99866093 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human CYP3A4,CYP3A5 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070419 Ensembl Gene Model | MGI Sequence Detail 45648 C57BL/6J ±  kb
transcript ENSMUST00000079268 Ensembl | MGI Sequence Detail 1986 Not Applicable  
polypeptide ENSMUSP00000078251 Ensembl | MGI Sequence Detail 503 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 29
    Gene Ontology 2
    Phenotypes 20
  • Earliest
    J:127366 van Herwaarden AE, et al., Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism. J Clin Invest. 2007 Nov;117(11):3583-92
  • Latest
    J:345093 Heintz MM, et al., Human CYP2B6 produces oxylipins from polyunsaturated fatty acids and reduces diet-induced obesity. PLoS One. 2022;17(12):e0277053
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory