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Cyp3a57 Gene Detail
Summary
  • Symbol
    Cyp3a57
  • Name
    cytochrome P450, family 3, subfamily a, polypeptide 57
  • Synonyms
    EG622127
  • Feature Type
    protein coding gene
  • IDs
    MGI:3646373
    NCBI Gene: 622127
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:145345279-145390926 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 85.17 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    307 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3646373
protein coding gene Chr5:145345149-145390926 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030366
protein coding gene Chr5:150780774-150832097 (+)
A/J MGP_AJ_G0030335
protein coding gene Chr5:144302051-144350853 (+)
AKR/J MGP_AKRJ_G0030268
protein coding gene Chr5:148807368-148852829 (+)
BALB/cJ MGP_BALBcJ_G0030352
protein coding gene Chr5:145569054-145620151 (+)
C3H/HeJ MGP_C3HHeJ_G0030063
protein coding gene Chr5:149618472-149692316 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030797
protein coding gene Chr5:156285177-156341450 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028018
protein coding gene Chr5:138740521-138805226 (+)
CAST/EiJ MGP_CASTEiJ_G0029468
protein coding gene Chr5:149196555-149276401 (+)
CBA/J MGP_CBAJ_G0030033
protein coding gene Chr5:162735355-163686621 (+)
DBA/2J MGP_DBA2J_G0030184
protein coding gene Chr5:144012022-144058233 (+)
FVB/NJ MGP_FVBNJ_G0030138
protein coding gene Chr5:143260984-143309954 (+)
LP/J MGP_LPJ_G0030272
protein coding gene Chr5:151373505-151446472 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030169
protein coding gene Chr5:165049120-165098835 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030838
protein coding gene Chr5:148730355-148776566 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0029021
protein coding gene Chr5:146827751-146869355 (-)
WSB/EiJ MGP_WSBEiJ_G0029543
protein coding gene Chr5:149517129-149564331 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070419 Ensembl Gene Model | MGI Sequence Detail 45648 C57BL/6J ±  kb
transcript ENSMUST00000079268 Ensembl | MGI Sequence Detail 1986 Not Applicable  
polypeptide ENSMUSP00000078251 Ensembl | MGI Sequence Detail 503 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR001128 Cytochrome P450
    IPR017972 Cytochrome P450, conserved site
    IPR008072 Cytochrome P450, E-class, CYP3A
    IPR002402 Cytochrome P450, E-class, group II
    IPR036396 Cytochrome P450 superfamily
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 20
    Gene Ontology 2
    Phenotypes 11
  • Earliest
    J:127366 van Herwaarden AE, et al., Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism. J Clin Invest. 2007 Nov;117(11):3583-92
  • Latest
    J:247967 Kumar R, et al., Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-null, and Cyp2b9/10/13-null mice. PLoS One. 2017;12(3):e0174355

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory