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Eef1akmt3 Gene Detail
Summary
  • Symbol
    Eef1akmt3
  • Name
    EEF1A lysine methyltransferase 3
  • Synonyms
    EG546486, Fam119b, Gm16109, Mettl21b
  • Feature Type
    protein coding gene
  • IDs
    MGI:3645330
    NCBI Gene: 100504608
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr10:127032806-127042026 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 74.50 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3645330
protein coding gene Chr10:127031004-127042026 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017800
protein coding gene Chr10:130605511-130617571 (-)
A/J MGP_AJ_G0017775
protein coding gene Chr10:125375030-125385491 (-)
AKR/J MGP_AKRJ_G0017738
protein coding gene Chr10:129085879-129096187 (-)
BALB/cJ MGP_BALBcJ_G0017739
protein coding gene Chr10:125782351-125792810 (-)
C3H/HeJ MGP_C3HHeJ_G0017563
protein coding gene Chr10:129218543-129230469 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018194
protein coding gene Chr10:135034489-135046611 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015874
protein coding gene Chr10:119398589-119409134 (-)
CAST/EiJ MGP_CASTEiJ_G0017123
protein coding gene Chr10:129869978-129880186 (-)
CBA/J MGP_CBAJ_G0017532
protein coding gene Chr10:140448469-140460002 (-)
DBA/2J MGP_DBA2J_G0017638
protein coding gene Chr10:124462764-124473131 (-)
FVB/NJ MGP_FVBNJ_G0017633
protein coding gene Chr10:123414166-123424607 (-)
LP/J MGP_LPJ_G0017712
protein coding gene Chr10:131174275-131186455 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017661
protein coding gene Chr10:143188966-143199440 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018234
protein coding gene Chr10:129142886-129153366 (-)
PWK/PhJ MGP_PWKPhJ_G0016908
protein coding gene Chr10:124652279-124664238 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016700
protein coding gene Chr10:128166927-128180260 (-)
WSB/EiJ MGP_WSBEiJ_G0017184
protein coding gene Chr10:129366487-129378017 (-)



Homology
more
  • Human Ortholog
    EEF1AKMT3, EEF1A lysine methyltransferase 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    EEF1AKMT3, EEF1A lysine methyltransferase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FAM119B, METTL21B
  • Links
    NCBI Gene ID: 25895
    neXtProt AC: NX_Q96AZ1
    UniProt: Q96AZ1

  • Chr Location
    12q14.1; chr12:57772600-57782541 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 100504608 NCBI Gene Model | MGI Sequence Detail 9221 C57BL/6J ±  kb
transcript NM_001205036 RefSeq | MGI Sequence Detail 699 C57BL/6  
polypeptide D3YWP0 UniProt | EBI | MGI Sequence Detail 232 Not Applicable  
For the selected sequence
Protein
Information
less
Other
Accession IDs
less
MGI:3801838
References
more
  • Summaries
    All 15
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:240550 Malecki J, et al., The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A). Nucleic Acids Res. 2017 Jan 20;45(8):4370-4389

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory