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Tigit Gene Detail
Summary
  • Symbol
    Tigit
  • Name
    T cell immunoreceptor with Ig and ITIM domains
  • Synonyms
    ENSMUSG00000071552, Vstm3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3642260
    NCBI Gene: 100043314
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:43648867-43664146 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 28.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    92 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3642260
protein coding gene Chr16:43648861-43664416 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022828
protein coding gene Chr16:42354012-42371251 (-)
A/J MGP_AJ_G0022793
protein coding gene Chr16:40440678-40456941 (-)
AKR/J MGP_AKRJ_G0022765
protein coding gene Chr16:41757139-41773178 (-)
BALB/cJ MGP_BALBcJ_G0022794
protein coding gene Chr16:40438601-40454352 (-)
C3H/HeJ MGP_C3HHeJ_G0022558
protein coding gene Chr16:41941851-41957636 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023241
protein coding gene Chr16:43333912-43350813 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020756
protein coding gene Chr16:40519537-40533924 (-)
CAST/EiJ MGP_CASTEiJ_G0022084
protein coding gene Chr16:42146365-42161937 (-)
CBA/J MGP_CBAJ_G0022529
protein coding gene Chr16:45175684-45195421 (-)
DBA/2J MGP_DBA2J_G0022661
protein coding gene Chr16:40171989-40190932 (-)
FVB/NJ MGP_FVBNJ_G0022636
protein coding gene Chr16:40160963-40175278 (-)
LP/J MGP_LPJ_G0022729
protein coding gene Chr16:42065527-42082595 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022655
protein coding gene Chr16:44572686-44589638 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023256
protein coding gene Chr16:41768308-41784591 (-)
PWK/PhJ MGP_PWKPhJ_G0021824
protein coding gene Chr16:40579346-40594683 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021655
protein coding gene Chr16:41672305-41691652 (-)
WSB/EiJ MGP_WSBEiJ_G0022128
protein coding gene Chr16:41871575-41888123 (-)



Homology
more
  • Human Ortholog
    TIGIT, T cell immunoreceptor with Ig and ITIM domains
  • Vertebrate Orthologs
    6
  • Human Ortholog
    TIGIT, T cell immunoreceptor with Ig and ITIM domains
    Orthology source: HomoloGene, HGNC
  • Synonyms
    VSIG9, VSTM3, WUCAM
  • Links
    NCBI Gene ID: 201633
    neXtProt AC: NX_Q495A1
    UniProt: Q495A1

  • Chr Location
    3q13.31; chr3:114293986-114310288 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased T cell proliferation, antigen presenting cell stimuation of T cell proliferation, and susceptibility to EAE.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071552 Ensembl Gene Model | MGI Sequence Detail 15280 C57BL/6J ±  kb
transcript ENSMUST00000096065 Ensembl | MGI Sequence Detail 919 Not Applicable  
polypeptide ENSMUSP00000093770 Ensembl | MGI Sequence Detail 241 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 31
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:150317 Yu X, et al., The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol. 2009 Jan;10(1):48-57
  • Latest
    J:274776 Mittal D, et al., CD96 Is an Immune Checkpoint That Regulates CD8(+) T-cell Antitumor Function. Cancer Immunol Res. 2019 Apr;7(4):559-571

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory