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Sh2d1b2 Gene Detail
Summary
  • Symbol
    Sh2d1b2
  • Name
    SH2 domain containing 1B2
  • Synonyms
    Eat2b, Ert, Sh2d1c
  • Feature Type
    protein coding gene
  • IDs
    MGI:3622649
    NCBI Gene: 545378
  • Gene Overview
    MyGene.info: SH2D1B
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr1:170232871-170251587 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 76.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3622649
protein coding gene Chr1:170232749-170253608 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016727
protein coding gene Chr1:175925911-175949320 (+)
A/J MGP_AJ_G0016707
protein coding gene Chr1:168748714-168773336 (+)
AKR/J MGP_AKRJ_G0016673
protein coding gene Chr1:173816416-173869426 (+)
BALB/cJ MGP_BALBcJ_G0016668
protein coding gene Chr1:169232238-169259269 (+)
C3H/HeJ MGP_C3HHeJ_G0016492
protein coding gene Chr1:174062995-174086454 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017129
protein coding gene Chr1:181752589-181775952 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014838
protein coding gene Chr1:160489573-160508522 (+)
CAST/EiJ MGP_CASTEiJ_G0016072
protein coding gene Chr1:173695235-173718470 (+)
CBA/J MGP_CBAJ_G0016467
protein coding gene Chr1:188212645-188240100 (+)
DBA/2J MGP_DBA2J_G0016573
protein coding gene Chr1:167612455-167665176 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0016644
protein coding gene Chr1:177009472-177014939 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016596
protein coding gene Chr1:195551417-195572362 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017166
protein coding gene Chr1:173704535-173725606 (+)
PWK/PhJ MGP_PWKPhJ_G0015858
protein coding gene Chr1:166842046-166869058 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0016134
protein coding gene Chr1:173827681-173851387 (+)



Homology
more
  • Human Ortholog
    SH2D1B, SH2 domain containing 1B
  • Vertebrate Orthologs
    2
  • Human Ortholog
    SH2D1B, SH2 domain containing 1B
    Orthology source: HGNC
  • Synonyms
    EAT2
  • Links
    NCBI Gene ID: 117157
    neXtProt AC: NX_O14796
    UniProt: O14796

  • Chr Location
    1q23.3; chr1:162395266-162412138 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    2 involving Sh2d1b2
  • Find Mice (IMSR)
Homozygous mutation of this gene results in altered natural killer cell function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 545378 NCBI Gene Model | MGI Sequence Detail 18717 C57BL/6J ±  kb
transcript NM_001033499 RefSeq | MGI Sequence Detail 399 129/Sv  
polypeptide Q45HK4 UniProt | EBI | MGI Sequence Detail 132 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 24
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:110195 Roncagalli R, et al., Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor. Nat Immunol. 2005 Oct;6(10):1002-10
  • Latest
    J:259468 Wu N, et al., A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education. Nat Immunol. 2016 Apr;17(4):387-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory