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Mir451a Gene Detail
Summary
  • Symbol
    Mir451a
  • Name
    microRNA 451a
  • Synonyms
    mir 451, Mirn451, mmu-mir-451, mmu-mir-451a
Location &
Maps
more
  • Sequence Map
    Chr11:78073170-78073241 bp, + strand
  • From miRBase annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3619412
miRNA gene Chr11:78073170-78073241 (+)
129S1/SvImJ MGP_129S1SvImJ_G0007847
miRNA gene Chr11:79041851-79041922 (+)
A/J MGP_AJ_G0007842
miRNA gene Chr11:76029549-76029620 (+)
AKR/J MGP_AKRJ_G0007817
miRNA gene Chr11:78334500-78334571 (+)
BALB/cJ MGP_BALBcJ_G0007820
miRNA gene Chr11:76425604-76425675 (+)
C3H/HeJ MGP_C3HHeJ_G0007766
miRNA gene Chr11:78370944-78371015 (+)
C57BL/6NJ MGP_C57BL6NJ_G0007998
miRNA gene Chr11:81510792-81510863 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0007141
miRNA gene Chr11:73003830-73003901 (+)
CAST/EiJ MGP_CASTEiJ_G0007659
miRNA gene Chr11:78810048-78810119 (+)
CBA/J MGP_CBAJ_G0007738
miRNA gene Chr11:85067900-85067971 (+)
DBA/2J MGP_DBA2J_G0007773
miRNA gene Chr11:75611240-75611311 (+)
FVB/NJ MGP_FVBNJ_G0007790
miRNA gene Chr11:75194955-75195026 (+)
LP/J MGP_LPJ_G0007850
miRNA gene Chr11:79579492-79579563 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0007761
miRNA gene Chr11:85503696-85503767 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0007994
miRNA gene Chr11:78573094-78573165 (+)
PWK/PhJ MGP_PWKPhJ_G0007587
miRNA gene Chr11:76388854-76388925 (+)
SPRET/EiJ MGP_SPRETEiJ_G0007483
miRNA gene Chr11:78181038-78181109 (+)
WSB/EiJ MGP_WSBEiJ_G0007728
miRNA gene Chr11:78386391-78386462 (+)



Homology
more
  • Human Ortholog
    MIR451A, microRNA 451a
  • Human Ortholog
    MIR451A, microRNA 451a
    Orthology source: HGNC
  • Synonyms
    hsa-mir-451, hsa-mir-451a, MIR451, mir-451a, MIRN451
  • Links
    NCBI Gene ID: 574411

  • Chr Location
    chr17:28861369-28861440 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 4 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired terminal erythropoeisis associated with decreased erythrocyte numbers, decreased hematocrit, increased red blood cell distribution width, enlarged spleen, and increased erythroid progenitor cells inthe spleen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 723870 NCBI Gene Model | MGI Sequence Detail 72 C57BL/6J ±  kb
    transcript NR_029971 RefSeq | MGI Sequence Detail 72 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 1
      Other 1
    Other Database
    Links
    less
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:270241 Zeng N, et al., MiR-451a attenuates free fatty acids-mediated hepatocyte steatosis by targeting the thyroid hormone responsive spot 14 gene. Mol Cell Endocrinol. 2018 Oct 15;474:260-271

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    08/06/2019
    MGI 6.14
    The Jackson Laboratory