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Prss58
Gene Detail
Symbol

Name
ID
Prss58
protease, serine 58
MGI:3608323
Synonyms
BC048599
Feature Type
protein coding gene
Genetic Map
Chromosome 6
18.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:40895270-40900387 bp, - strand
From VEGA annotation of GRCm38

  5118 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:65285  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: PRSS58
Protein SuperFamily: trypsin
Gene Tree: Prss58

Human
homologs
PRSS58, protease, serine, 58
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 136541
neXtProt AC: NX_Q8IYP2

Human Synonyms: PRSS1, TRY1, TRYX3, UNQ2540

Human Chr (Location): 7q34; chr7:142252138-142258058 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Prss58 interacts with 13 markers (Mir24-1, Mir24-2, Mir101a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process proteolysis
Component extracellular region
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000051415 (Evidence)
Ensembl Gene Model ENSMUSG00000051936 (Evidence)
Entrez Gene 232717 (Evidence)
UniGene 56997
DFCI TC1590156
DoTS DT.101722770
NIA Mouse Gene Index U063177
EC 3.4.21.4
Consensus CDS Project CCDS20040.1
International Mouse Phenotyping Consortium Status Prss58
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051415 VEGA Gene Model | MGI Sequence Detail 5118 C57BL/6J ±  kb
transcript OTTMUST00000129972 VEGA | MGI Sequence Detail 979 Not Applicable 
polypeptide OTTMUSP00000069737 VEGA | MGI Sequence Detail 241 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(3) UniProt(1)
Polymorphisms
SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR009003 Peptidase S1, PA clan
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR001254 Serine proteases, trypsin domain
Protein Ontology PR:000016707 serine protease 58
References
(Earliest) J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(25)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory