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Prss58
Gene Detail
Symbol

Name
ID
Prss58
protease, serine 58
MGI:3608323
Synonyms
BC048599
Feature Type
protein coding gene
Genetic Map
Chromosome 6
18.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:40895270-40900387 bp, - strand
From VEGA annotation of GRCm38

  5118 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:65285  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: trypsin
Gene Tree: Prss58

Human
homologs
Human Homolog   PRSS58, protease, serine, 58
NCBI Gene ID 136541
neXtProt AC  NX_Q8IYP2
Human Synonyms  PRSS1, TRY1, TRYX3, UNQ2540
Human Chr (Location)  7q34; chr7:142252138-142258058 (-)  GRCh38.p2
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Prss58 interacts with 13 markers (Mir24-1, Mir24-2, Mir101a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process proteolysis
Component extracellular region
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000051415 (Evidence)
Ensembl Gene ModelENSMUSG00000051936 (Evidence)
Entrez Gene232717 (Evidence)
UniGene56997
DFCITC1590156
DoTSDT.101722770
NIA Mouse Gene IndexU063177
EC3.4.21.4
Consensus CDS ProjectCCDS20040.1
International Mouse Knockout Project StatusPrss58
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051415 VEGA Gene Model | MGI Sequence Detail 5118 C57BL/6J ±  kb
transcript OTTMUST00000129972 VEGA | MGI Sequence Detail 979 Not Applicable 
polypeptide OTTMUSP00000069737 VEGA | MGI Sequence Detail 241 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(3) UniProt(1)
Polymorphisms
SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000016707 serine protease 58
References
(Earliest) J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory