Dok7
Gene Detail

Symbol Name ID

Dok7 docking protein 7 MGI:3584043

Synonyms

A930013K19Rik, Dok-7, EF-12, Oit5

Feature Type

protein coding gene

Genetic Map

Chromosome 5

18.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:35056813-35087839 bp, + strand From VEGA annotation of GRCm38   31027 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:18210  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dok7

Human homologs

Human Homolog		DOK7, docking protein 7
NCBI Gene ID		285489
neXtProt AC		NX_Q18PE1
Human Synonyms		C4orf25, CMS1B
Human Chr (Location)		4p16.3; chr4:3465033-3496209 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human DOK7

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Homozygous mutation of this gene results in death shortly after birth, impaired neuromuscular synaptogenesis and akinesia.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	neuromuscular junction development, positive regulation of protein phosphorylation, ...
Component	cell junction, membrane, ...
Function	insulin receptor binding, lipid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (12)    Tissues (12)   
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
Northern blot	12

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) Genomic(1) cDNA(14)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000022794 (Evidence)
Ensembl Gene Model	ENSMUSG00000044716 (Evidence)
Entrez Gene	231134 (Evidence)
UniGene	205483
DFCI	TC1581722, TC1590875
DoTS	DT.101165588, DT.40175217, DT.55248964
NIA Mouse Gene Index	U005496
PDB	3ML4
Consensus CDS Project	CCDS19224.1
International Mouse Knockout Project Status	Dok7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022794	VEGA Gene Model | MGI Sequence Detail	31027	C57BL/6J
transcript	OTTMUST00000054759	VEGA | MGI Sequence Detail	2498	Not Applicable
polypeptide	OTTMUSP00000026162	VEGA | MGI Sequence Detail	570	Not Applicable

All sequences(43) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(95 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002404	Insulin receptor substrate-1, PTB
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
Protein Ontology	PR:000006634	protein Dok-7

References

(Earliest) J:44165 Fu X, et al., E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. Mol Cell Biol. 1997 Mar;17(3):1503-12
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(31)

Other accession IDs

MGI:1201798, MGI:2141134