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Dok7
Gene Detail
 Symbol
Name
ID
Dok7
docking protein 7
MGI:3584043
Synonyms A930013K19Rik, Dok-7, EF-12, Oit5
Feature Type protein coding gene
Genetic Map
Chromosome 5
18.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:35056813-35087839 bp, + strand
From VEGA annotation of GRCm38

  31027 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18210  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: Dok7

Human
homologs
Human Homolog DOK7, docking protein 7
NCBI Gene ID 285489
neXtProt AC  NX_Q18PE1
Human Synonyms  C4orf25, CMS1B
Human Chr (Location)  4p16.3; chr4:3463306-3494482 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human DOK7
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Radiation induced(4) Targeted(2)
Genomic Mutations involving Dok7 (5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in death shortly after birth, impaired neuromuscular synaptogenesis and akinesia.
 
Alleles Annotated to Human Diseases(4)   
Interactions
Dok7 interacts with 159 markers (Mir10a, Mir10b, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process neuromuscular junction development, positive regulation of protein phosphorylation, ...
Component cell junction, membrane, ...
Function insulin receptor binding, lipid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (12)    Tissues (12)   
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
Northern blot 12
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(13)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022794 (Evidence)
Ensembl Gene ModelENSMUSG00000044716 (Evidence)
Entrez Gene231134 (Evidence)
UniGene205483
DFCITC1581722, TC1590875
DoTSDT.101165588, DT.40175217, DT.55248964
NIA Mouse Gene IndexU005496
PDB3ML4
Consensus CDS ProjectCCDS19224.1
International Mouse Knockout Project StatusDok7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022794 VEGA Gene Model | MGI Sequence Detail 31027 C57BL/6J ±  kb
transcript OTTMUST00000054759 VEGA | MGI Sequence Detail 2498 Not Applicable 
polypeptide OTTMUSP00000026162 VEGA | MGI Sequence Detail 570 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(12) UniProt(3)
Polymorphisms SNPs within 2kb(108 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002404 Insulin receptor substrate-1, PTB
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000006634 protein Dok-7
References (Earliest) J:44165 Fu X, et al., E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. Mol Cell Biol. 1997 Mar;17(3):1503-12
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(32)
Other
accession IDs
MGI:1201798, MGI:2141134

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory