Best3
Gene Detail

Symbol Name ID

Best3 bestrophin 3 MGI:3580298

Synonyms

mBest4, Vmd2l3

Feature Type

protein coding gene

Genetic Map

Chromosome 10

65.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr10:116986314-117025040 bp, + strand From NCBI annotation of GRCm38   38727 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:33850  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Best3

Human homologs

Human Homolog		BEST3, bestrophin 3
NCBI Gene ID		144453
neXtProt AC		NX_Q8N1M1
Human Synonyms		VMD2L3
Human Chr (Location)		12q14.2-q15; chr12:70047389-70093196 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(3) Gene trapped(3)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	chloride transport, inorganic anion transport, ...
Component	chloride channel complex, integral to membrane, ...
Function	chloride channel activity, ion channel activity

External Resources: FuncBase

Expression

cDNA source data(1)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(3) cDNA(1) Other(2)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000020169 (Evidence)
Entrez Gene	382427 (Evidence)
UniGene	339322
DoTS	DT.103581506
NIA Mouse Gene Index	U112489
Consensus CDS Project	CCDS24188.1
International Mouse Knockout Project Status	Best3

Sequences

Length	Strain/Species
genomic	382427	NCBI Gene Model | MGI Sequence Detail	38727	C57BL/6J
transcript	NM_001007583	RefSeq | MGI Sequence Detail	2719	C57BL/6
polypeptide	Q6H1V1	UniProt | EBI | MGI Sequence Detail	669	Not Applicable

All sequences(12) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(295 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000615	Bestrophin
InterPro	IPR021134	Bestrophin/UPF0187
Protein Ontology	PR:000004723	bestrophin-3

Graphical View of Protein Domain Structure

References

(Earliest) J:98703 Stohr H, et al., Three novel human VMD2-like genes are members of the evolutionary highly conserved RFP-TM family. Eur J Hum Genet. 2002 Apr;10(4):281-4
(Latest) J:143792 O'Driscoll KE, et al., Expression, localization, and functional properties of Bestrophin 3 channel isolated from mouse heart. Am J Physiol Cell Physiol. 2008 Dec;295(6):C1610-24
All references(26)