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Best3 Gene Detail
Summary
  • Symbol
    Best3
  • Name
    bestrophin 3
  • Synonyms
    mBest4, Vmd2l3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3580298
    NCBI Gene: 382427
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:116986314-117025040 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 65.00 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    512 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3580298
protein coding gene Chr10:116986314-117025687 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017750
protein coding gene Chr10:119800369-119841097 (+)
A/J MGP_AJ_G0017726
protein coding gene Chr10:115181630-115220176 (+)
AKR/J MGP_AKRJ_G0017688
protein coding gene Chr10:118529036-118568300 (+)
BALB/cJ MGP_BALBcJ_G0017689
protein coding gene Chr10:115580307-115619126 (+)
C3H/HeJ MGP_C3HHeJ_G0017514
protein coding gene Chr10:118753209-118792656 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018146
protein coding gene Chr10:123963852-124005168 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015825
protein coding gene Chr10:109771298-109813051 (+)
CAST/EiJ MGP_CASTEiJ_G0017076
protein coding gene Chr10:119063495-119114036 (+)
CBA/J MGP_CBAJ_G0017483
protein coding gene Chr10:128840950-128881810 (+)
DBA/2J MGP_DBA2J_G0017588
protein coding gene Chr10:114320823-114358486 (+)
FVB/NJ MGP_FVBNJ_G0017583
protein coding gene Chr10:113274097-113311691 (+)
LP/J MGP_LPJ_G0017663
protein coding gene Chr10:120388727-120430363 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017612
protein coding gene Chr10:131706321-131747541 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018184
protein coding gene Chr10:118595114-118637693 (+)
PWK/PhJ MGP_PWKPhJ_G0016858
protein coding gene Chr10:114419296-114458557 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016648
protein coding gene Chr10:117406547-117445681 (+)
WSB/EiJ MGP_WSBEiJ_G0017136
protein coding gene Chr10:118794002-118837684 (+)



Homology
more
  • Human Ortholog
    BEST3, bestrophin 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BEST3, bestrophin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    VMD2L3
  • Links
    NCBI Gene ID: 144453
    neXtProt AC: NX_Q8N1M1
    UniProt: Q8N1M1

  • Chr Location
    12q15; chr12:69643508-69699416 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020169 Ensembl Gene Model | MGI Sequence Detail 38727 C57BL/6J ±  kb
transcript ENSMUST00000020378 Ensembl | MGI Sequence Detail 2719 Not Applicable  
polypeptide ENSMUSP00000020378 Ensembl | MGI Sequence Detail 669 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 1
    cDNA 1

    Microarray probesets 1
References
more
  • Summaries
    All 26
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:143792 O'Driscoll KE, et al., Expression, localization, and functional properties of Bestrophin 3 channel isolated from mouse heart. Am J Physiol Cell Physiol. 2008 Dec;295(6):C1610-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory