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Itgad
Gene Detail
Symbol

Name
ID
Itgad
integrin, alpha D
MGI:3578624
Synonyms
Cd11d
Feature Type
protein coding gene
Genetic Map
Chromosome 7
70.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:128154376-128223816 bp, + strand
From VEGA annotation of GRCm38

  69441 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56919  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog

Protein SuperFamily: integrin alpha with I domain
Gene Tree: Itgad

Human
homologs
Human Homolog ITGAD, integrin, alpha D
NCBI Gene ID 3681
neXtProt AC  NX_Q13349
Human Synonyms  ADB2, CD11D
Human Chr (Location)  16p11.2; chr16:31393312-31426505 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit a reduced staphylococcal enterotoxin-induced T cell response.
 
Interactions
Itgad interacts with 91 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process activated T cell proliferation, cell adhesion, ...
Component integral component of membrane, integrin complex, ...
Function metal ion binding, protein heterodimerization activity
External Resources: FuncBase
Expression
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(5) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000042024 (Evidence)
Ensembl Gene ModelENSMUSG00000070369 (Evidence)
Entrez Gene381924 (Evidence)
UniGene334257
DFCITC1586907
NIA Mouse Gene IndexU079846
Consensus CDS ProjectCCDS21890.2, CCDS52411.1
International Mouse Knockout Project StatusItgad
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042024 VEGA Gene Model | MGI Sequence Detail 69441 C57BL/6J ±  kb
transcript OTTMUST00000110161 VEGA | MGI Sequence Detail 3965 Not Applicable 
polypeptide OTTMUSP00000061405 VEGA | MGI Sequence Detail 1202 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(7) UniProt(11)
Polymorphisms
SNPs within 2kb(747 from dbSNP Build 137)    SNPs within 2kb including multiple locations(765)
Protein-related
information
ResourceIDDescription
InterPro IPR013517 FG-GAP repeat
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000001009 integrin alpha-D
References
(Earliest) J:90954 Wu H, et al., Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes. J Immunol. 2004 Jul 1;173(1):297-306
(Latest) J:172212 Thomas AP, et al., Inflammatory Phenotyping Identifies CD11d as a Gene Markedly Induced in White Adipose Tissue in Obese Rodents and Women. J Nutr. 2011 Jun;141(6):1172-80
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory