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Itgad Gene Detail
Summary
  • Symbol
    Itgad
  • Name
    integrin, alpha D
  • Synonyms
    Cd11d
  • Feature Type
    protein coding gene
  • IDs
    MGI:3578624
    NCBI Gene: 381924
  • Gene Overview
    MyGene.info: ITGAD
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:128173933-128205504 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 70.00 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    395 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3578624
protein coding gene Chr7:128154376-128223816 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033074
protein coding gene Chr7:132560558-132629889 (+)
A/J MGP_AJ_G0033056
protein coding gene Chr7:128995793-129067858 (+)
AKR/J MGP_AKRJ_G0032988
protein coding gene Chr7:132357957-132444978 (+)
BALB/cJ MGP_BALBcJ_G0033057
protein coding gene Chr7:128659700-128732696 (+)
C3H/HeJ MGP_C3HHeJ_G0032771
protein coding gene Chr7:132255734-132329071 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033567
protein coding gene Chr7:137721684-137804624 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030539
protein coding gene Chr7:130184214-130231983 (+)
CAST/EiJ MGP_CASTEiJ_G0032101
protein coding gene Chr7:124043765-124118904 (+)
CBA/J MGP_CBAJ_G0032744
protein coding gene Chr7:142419946-142502135 (+)
DBA/2J MGP_DBA2J_G0032896
protein coding gene Chr7:126986368-127057637 (+)
FVB/NJ MGP_FVBNJ_G0032849
protein coding gene Chr7:126846282-126916354 (+)
LP/J MGP_LPJ_G0032990
protein coding gene Chr7:134036447-134109900 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032881
protein coding gene Chr7:143469165-143539428 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033586
protein coding gene Chr7:131333769-131406831 (+)
PWK/PhJ MGP_PWKPhJ_G0031807
protein coding gene Chr7:119987021-120065452 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031653
protein coding gene Chr7:118131332-118210299 (+)
WSB/EiJ MGP_WSBEiJ_G0032212
protein coding gene Chr7:132304301-132385272 (+)



Homology
more
  • Human Ortholog
    ITGAD, integrin subunit alpha D
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ITGAD, integrin subunit alpha D
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADB2, CD11D
  • Links
    NCBI Gene ID: 3681
    neXtProt AC: NX_Q13349
    UniProt: Q13349

  • Chr Location
    16p11.2; chr16:31393224-31426513 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit a reduced staphylococcal enterotoxin-induced T cell response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 381924 NCBI Gene Model | MGI Sequence Detail 31572 C57BL/6J ±  kb
transcript NM_001029872 RefSeq | MGI Sequence Detail 3975 C57BL/6  
polypeptide Q3V0T4 UniProt | EBI | MGI Sequence Detail 1168 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR013517 FG-GAP repeat
    IPR013649 Integrin alpha-2
    IPR013519 Integrin alpha beta-propellor
    IPR000413 Integrin alpha chain
    IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
    IPR028994 Integrin alpha, N-terminal
    IPR032695 Integrin domain superfamily
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR002035 von Willebrand factor, type A
Molecular
Reagents
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  • All nucleic 6
    cDNA 6

    Microarray probesets 3
References
more
  • Summaries
    All 26
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:90954 Wu H, et al., Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes. J Immunol. 2004 Jul 1;173(1):297-306
  • Latest
    J:247721 Aziz MH, et al., The Upregulation of Integrin alphaDbeta2 (CD11d/CD18) on Inflammatory Macrophages Promotes Macrophage Retention in Vascular Lesions and Development of Atherosclerosis. J Immunol. 2017 Jun 15;198(12):4855-4867

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory