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Itgad Gene Detail
Summary
  • Symbol
    Itgad
  • Name
    integrin, alpha D
  • Synonyms
    Cd11d
  • Feature Type
    protein coding gene
  • IDs
    MGI:3578624
    NCBI Gene: 381924
Location & Maps
more
  • Sequence Map
    Chr7:128154376-128223816 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      69441 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ITGAD, integrin subunit alpha D
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ITGAD, integrin subunit alpha D
    Orthology source: HomoloGene
  • Synonyms
    ADB2, CD11D
  • Links
    NCBI Gene ID: 3681
    neXtProt AC: NX_Q13349

  • Chr Location
    16p11.2; chr16:31393241-31426513 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit a reduced staphylococcal enterotoxin-induced T cell response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042024 VEGA Gene Model | MGI Sequence Detail 69441 C57BL/6J ±  kb
transcript OTTMUST00000110161 VEGA | MGI Sequence Detail 3965 Not Applicable  
polypeptide OTTMUSP00000061405 VEGA | MGI Sequence Detail 1202 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    747 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
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  • All nucleic 6
    cDNA 5
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 25
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:90954 Wu H, et al., Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes. J Immunol. 2004 Jul 1;173(1):297-306
  • Latest
    J:172212 Thomas AP, et al., Inflammatory Phenotyping Identifies CD11d as a Gene Markedly Induced in White Adipose Tissue in Obese Rodents and Women. J Nutr. 2011 Jun;141(6):1172-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory