Itgad Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Itgad
integrin, alpha D
MGI:3578624

13 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Itgad^tm1.1Zimm/Itgad^tm1.1Zimm involves: 129S6/SvEvTac * C57BL/6	abnormal immune system physiology	J:130908
	abnormal macrophage physiology	J:130908
	abnormal susceptibility to infection	J:130908
	decreased susceptibility to parasitic infection	J:130908
	increased circulating interleukin-12 level	J:130908
	increased spleen weight	J:130908
	increased susceptibility to bacterial infection	J:130908
Itgad^tm1Bll/Itgad^tm1Bll B6.129S7-Itgad^tm1Bll	abnormal lymphocyte cell number	J:90954
	abnormal T cell activation	J:90954
	abnormal T cell subpopulation ratio	J:90954
	decreased CD4-positive, alpha-beta T cell number	J:90954
	decreased T cell proliferation	J:90954
	increased CD8-positive, alpha-beta T cell number	J:90954

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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