Itgad^tm1.1Zimm
Targeted Allele Detail

Summary

• Symbol: Itgad^tm1.1Zimm
• Name: integrin, alpha D; targeted mutation 1.1, Guy Zimmerman
• MGI ID: MGI:3810325
• Synonyms: alphaD^-
• Gene: Itgad Location: Chr7:127773105-127822988 bp, + strand Genetic Position: Chr7, 70.0 cM
• Alliance: Itgad^tm1.1Zimm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130908
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neomycin selection cassette and three stop codons were inserted in exon 6. Mice derived from correctly targeted ES cells were crossed to mice carrying Tg(CMV-cre)1Cgn in order to excise the selection cassette. (J:130908)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgad Mutation: 67 strains or lines available

References

• Original: J:130908 Miyazaki Y, et al., Integrin alphaDbeta2 is dynamically expressed by inflamed macrophages and alters the natural history of lethal systemic infections. J Immunol. 2008 Jan 1;180(1):590-600
• All: 1 reference(s)