Phenotypes associated with this allele

• Allele Symbol: Itgad^tm1.1Zimm
• Allele Name: targeted mutation 1.1, Guy Zimmerman
• Allele ID: MGI:3810325
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgad^tm1.1Zimm/Itgad^tm1.1Zimm	involves: 129S6/SvEvTac * C57BL/6	MGI:3810331

Genotype
MGI:3810331

hm1

• Allelic Composition: Itgad^tm1.1Zimm/Itgad^tm1.1Zimm
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased spleen weight ( J:130908 )

• elevated spleen weights at 10-11 weeks of age

• normal spleen weights at 17-18 weeks

abnormal immune system physiology ( J:130908 )

abnormal macrophage physiology ( J:130908 )

• macrophage are much less adherent

increased circulating interleukin-12 level ( J:130908 )

• reduced concentration in the blood of mice infected with Plasmodium berghei

abnormal susceptibility to infection ( J:130908 )

increased susceptibility to bacterial infection ( J:130908 )

• increased susceptibility to Salmonella typhimurium relative to controls

decreased susceptibility to parasitic infection ( J:130908 )

• increased resistance to Plasmodium berghei relative to controls

homeostasis/metabolism

increased circulating interleukin-12 level ( J:130908 )

• reduced concentration in the blood of mice infected with Plasmodium berghei

hematopoietic system

increased spleen weight ( J:130908 )

• elevated spleen weights at 10-11 weeks of age

• normal spleen weights at 17-18 weeks

abnormal macrophage physiology ( J:130908 )

• macrophage are much less adherent

growth/size/body

increased spleen weight ( J:130908 )

• elevated spleen weights at 10-11 weeks of age

• normal spleen weights at 17-18 weeks