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Grxcr1
Gene Detail
Symbol

Name
ID
Grxcr1
glutaredoxin, cysteine rich 1
MGI:3577767
Synonyms
pi, tde
Feature Type
protein coding gene
Genetic Map
Chromosome 5
36.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr5:68031835-68166398 bp, + strand
From VEGA annotation of GRCm38

  134564 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:42423  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Grxcr1

Human
homologs
Human Homolog GRXCR1, glutaredoxin, cysteine rich 1
NCBI Gene ID 389207
neXtProt AC  NX_A8MXD5
Human Synonyms  DFNB25, PPP1R88
Human Chr (Location)  4p13; chr4:42893266-43030658 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GRXCR1
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(1) Spontaneous(4) Targeted(5) Transgenic(2)
Incidental mutations (data from APF )
 
Homozygous mutations at this locus result in circling and head tossing behavior, and impaired hearing.
 
Interactions
Grxcr1 interacts with 44 markers (Mir98, Mir143, Mir203, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process auditory receptor cell differentiation, cell redox homeostasis, ...
Component cell projection, cilium, ...
Function electron carrier activity, protein disulfide oxidoreductase activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (7)    Tissues (2)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(3) cDNA(3)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000034596 (Evidence)
Ensembl Gene ModelENSMUSG00000068082 (Evidence)
Entrez Gene433899 (Evidence)
UniGene332422
DFCITC1594340
DoTSDT.91413405
NIA Mouse Gene IndexU123439
Consensus CDS ProjectCCDS19319.2
International Mouse Knockout Project StatusGrxcr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034596 VEGA Gene Model | MGI Sequence Detail 134564 C57BL/6J ±  kb
transcript OTTMUST00000087762 VEGA | MGI Sequence Detail 1071 Not Applicable 
polypeptide OTTMUSP00000047777 VEGA | MGI Sequence Detail 296 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(892 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002109 Glutaredoxin
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000030464 glutaredoxin domain-containing cysteine-rich protein 1
References
(Earliest) J:13131 Woolley GW, et al., Pirouetting mice. J Hered. 1945;36:281-284
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(44)
Other
accession IDs
MGD-MRK-13302, MGI:1891240, MGI:3513401, MGI:97581

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory