Grxcr1
Gene Detail

Symbol Name ID

Grxcr1 glutaredoxin, cysteine rich 1 MGI:3577767

Synonyms

pi, tde

Feature Type

protein coding gene

Genetic Map

Chromosome 5

36.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr5:68031835-68166398 bp, + strand From VEGA annotation of GRCm38   134564 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:42423  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Grxcr1

Human homologs

Human Homolog		GRXCR1, glutaredoxin, cysteine rich 1
NCBI Gene ID		389207
neXtProt AC		NX_A8MXD5
Human Synonyms		DFNB25
Human Chr (Location)		4p13; chr4:42895283-43032675 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GRXCR1

Alleles and phenotypes

All alleles(11) : Targeted(4) Gene trapped(1) Transgenic(2) Spontaneous(4)
 

Homozygous mutations at this locus result in circling and head tossing behavior, and impaired hearing.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	auditory receptor cell differentiation, cell redox homeostasis, ...
Component	cell projection, cilium, ...
Function	electron carrier activity, protein disulfide oxidoreductase activity

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (7)    Tissues (2)    Images (6)
Theiler Stages: 23

Assay Type	Results
RNA in situ	7

cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(3) cDNA(3)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000034596 (Evidence)
Ensembl Gene Model	ENSMUSG00000068082 (Evidence)
Entrez Gene	433899 (Evidence)
UniGene	332422
DFCI	TC1594340
DoTS	DT.91413405
NIA Mouse Gene Index	U123439
Consensus CDS Project	CCDS19319.2
International Mouse Knockout Project Status	Grxcr1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034596	VEGA Gene Model | MGI Sequence Detail	134564	C57BL/6J
transcript	OTTMUST00000087762	VEGA | MGI Sequence Detail	1071	Not Applicable
polypeptide	OTTMUSP00000047777	VEGA | MGI Sequence Detail	296	Not Applicable

All sequences(23) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(575 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002109	Glutaredoxin
InterPro	IPR012336	Thioredoxin-like fold
Protein Ontology	PR:000030464	glutaredoxin domain-containing cysteine-rich protein 1

References

(Earliest) J:13131 Woolley GW, et al., Pirouetting mice. J Hered. 1945;36:281-284
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(43)

Other accession IDs

MGD-MRK-13302, MGI:1891240, MGI:3513401, MGI:97581