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Cdsn Gene Detail
Summary
  • Symbol
    Cdsn
  • Name
    corneodesmosin
  • Feature Type
    protein coding gene
  • IDs
    MGI:3505689
    NCBI Gene: 386463
Location & Maps
more
  • Sequence Map
    Chr17:35552128-35557180 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5053 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.70 cM
  • Mapping Data
    1 experiment
Homology
less
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 3 alleles in 4 genetic backgrounds
    6 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Gene trapped
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Cdsn
  • Incidental Mutations
Mice homozygous for a null mutation display neonatal lethality with epidermal detachment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037244 VEGA Gene Model | MGI Sequence Detail 5053 C57BL/6J ±  kb
transcript OTTMUST00000096049 VEGA | MGI Sequence Detail 2678 Not Applicable  
polypeptide OTTMUSP00000053625 VEGA | MGI Sequence Detail 561 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 5
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
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MGI:2146920
References
more
  • Summaries
    All 32
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:93050 Yang T, et al., Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice. Genes Dev. 2004 Oct 1;18(19):2354-8
  • Latest
    J:196481 Sevilla LM, et al., Epidermal inactivation of the glucocorticoid receptor triggers skin barrier defects and cutaneous inflammation. J Invest Dermatol. 2013 Feb;133(2):361-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory