Cdsn
Gene Detail

Symbol Name ID

Cdsn corneodesmosin MGI:3505689

Feature Type

protein coding gene

Genetic Map

Chromosome 17

18.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr17:35552128-35557180 bp, + strand From VEGA annotation of GRCm38   5053 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:48005  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: loricrin
Gene Tree: Cdsn

Human homologs

Human Homolog		CDSN, corneodesmosin
NCBI Gene ID		1041
neXtProt AC		NX_Q15517
Human Synonyms		D6S586E, HTSS, HTSS1, PSS, S
Human Chr (Location)		6p21.3; chr6:31082865-31088252 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human CDSN

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mice homozygous for a null mutation display neonatal lethality with epidermal detachment.

 
Phenotype Images(6)

Gene Ontology (GO) classifications

All GO classifications: (3 annotations)

Process	skin morphogenesis
Component	desmosome, extracellular region

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (3)    Tissues (2)   
Theiler Stages: 23, 24

Assay Type	Results
RT-PCR	3

cDNA source data(5)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000037244 (Evidence)
Ensembl Gene Model	ENSMUSG00000039518 (Evidence)
Entrez Gene	386463 (Evidence)
DFCI	TC1581535
DoTS	DT.101277645, DT.530500
NIA Mouse Gene Index	U043595
Consensus CDS Project	CCDS28699.1
International Mouse Knockout Project Status	Cdsn

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037244	VEGA Gene Model | MGI Sequence Detail	5053	C57BL/6J
transcript	OTTMUST00000096049	VEGA | MGI Sequence Detail	2678	Not Applicable
polypeptide	OTTMUSP00000053625	VEGA | MGI Sequence Detail	561	Not Applicable

All sequences(22) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(39 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026087	Corneodesmosin
Protein Ontology	PR:000005292	corneodesmosin

References

(Earliest) J:93050 Yang T, et al., Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice. Genes Dev. 2004 Oct 1;18(19):2354-8
(Latest) J:182938 Sevilla LM, et al., Glucocorticoid receptor regulates overlapping and differential gene subsets in developing and adult skin. Mol Endocrinol. 2010 Nov;24(11):2166-78
All references(32)

Other accession IDs

MGI:2146920