Akap6
Gene Detail

Symbol

Name
ID

Akap6
A kinase (PRKA) anchor protein 6
MGI:3050566

Feature Type

protein coding gene

Genetic Map

Chromosome 12
22.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:52699383-53151015 bp, + strand From Ensembl annotation of GRCm38   451633 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:3157  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Akap6

Human
homologs

Human Homolog		AKAP6, A kinase (PRKA) anchor protein 6
NCBI Gene ID		9472
neXtProt AC		NX_Q13023
Human Synonyms		ADAP100, ADAP6, AKAP100, mAKAP, PRKA6
Human Chr (Location)		14q12; chr14:32329273-32833062 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Targeted disruption of this gene results in partial embryonic lethality; surviving homozygotes display a decreased body weight, craniofacial defects and reduced viability.

 

Interactions

Akap6 interacts with 455 markers (Mir1b, Mir7-1, Mir7-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (61 annotations)

Process	cellular protein complex localization, cellular response to cAMP, ...
Component	calcium channel complex, caveola, ...
Function	adenylate cyclase binding, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (141)    Tissues (45)    Images (32)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	141

cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(10) cDNA(10)
Microarray probesets(3)

Other database
links

Ensembl Gene Model	ENSMUSG00000061603 (Evidence)
Entrez Gene	238161 (Evidence)
DFCI	TC1584605, TC1631010, TC1597699, TC1625266, TC1602619
DoTS	DT.101261446, DT.101735925
NIA Mouse Gene Index	U013946, U013944
Consensus CDS Project	CCDS36444.1
International Mouse Knockout Project Status	Akap6

Sequences

Length	Strain/Species
genomic	ENSMUSG00000061603	Ensembl Gene Model | MGI Sequence Detail	451633	C57BL/6J
transcript	ENSMUST00000095737	Ensembl | MGI Sequence Detail	10263	Not Applicable
polypeptide	ENSMUSP00000093406	Ensembl | MGI Sequence Detail	2307	Not Applicable

All sequences(52) RefSeq(20) UniProt(8)

Polymorphisms

SNPs within 2kb(5132 from dbSNP Build 137)    SNPs within 2kb including multiple locations(5146)

Protein-related
information

Resource	ID	Description
InterPro	IPR026696	A-kinase anchor protein 6/Centrosomal protein of 68kDa
InterPro	IPR018159	Spectrin/alpha-actinin
InterPro	IPR002017	Spectrin repeat
Protein Ontology	PR:000003893	A-kinase anchor protein 6

References

(Earliest) J:198914 Kapiloff MS, et al., mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope. J Cell Sci. 2001 Sep;114(Pt 17):3167-76
(Latest) J:214288 Kritzer MD, et al., The scaffold protein muscle A-kinase anchoring protein beta orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure. Circ Heart Fail. 2014 Jul;7(4):663-72
All references(36)

Other
accession IDs

MGI:2144849