Akap6 MGI Mouse Gene Detail - MGI:3050566 - A kinase (PRKA) anchor protein 6

Akap6 Gene Detail

Symbol

Akap6
Name

A kinase (PRKA) anchor protein 6

Feature Type

protein coding gene
IDs

MGI:3050566
NCBI Gene: 238161
Gene Overview

MyGene.info: AKAP6

Sequence Map

Chr12:52699383-53155599 bp, + strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
Download
Sequence

456217 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 22.18 cM
Mapping Data

2 experiments

Human Ortholog

AKAP6, A-kinase anchoring protein 6

Vertebrate Orthologs

10

Human Ortholog

AKAP6, A-kinase anchoring protein 6
Orthology source: HomoloGene, HGNC
Synonyms

ADAP100, ADAP6, AKAP100, mAKAP, PRKA6
Links

HGNC:376

NCBI Gene ID: 9472

neXtProt AC: NX_Q13023

UniProt: Q13023
Chr Location

14q12; chr14:32329273-32833999 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 3157
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: AKAP6
Gene Tree

Akap6

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Phenotype Summary

14 phenotypes from 3 alleles in 4 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Gene trapped

1
Targeted

4
Genomic Mutations

1 involving Akap6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

61 strains or lines available

Targeted disruption of this gene results in partial embryonic lethality; surviving homozygotes display a decreased body weight, craniofacial defects and reduced viability.

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All GO Annotations

61
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

141
Tissues

45
cDNA Data

9
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Akap6 interacts with 454 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

45
RefSeq

20
UniProt

8
CCDS

CCDS36444.1

Ensembl

ENSMUSG00000061603 (Evidence)
NCBI Gene

238161

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061603	Ensembl Gene Model \| MGI Sequence Detail	456217	C57BL/6J	± kb
transcript	ENSMUST00000095737	Ensembl \| MGI Sequence Detail	14847	Not Applicable
polypeptide	ENSMUSP00000093406	Ensembl \| MGI Sequence Detail	2307	Not Applicable

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SNPs within 2kb

5148 from dbSNP Build 142

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UniProt

8 Sequences
Protein Ontology

PR:000003893 A-kinase anchor protein 6

(term hierarchy)
InterPro Domains

IPR026696 A-kinase anchor protein 6/Centrosomal protein of 68kDa

IPR018159 Spectrin/alpha-actinin

IPR002017 Spectrin repeat

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All nucleic 10

cDNA 10

Microarray probesets 3

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MGI:2144849

Summaries

All 35

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 6
Earliest

J:198914 Kapiloff MS, et al., mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope. J Cell Sci. 2001 Sep;114(Pt 17):3167-76
Latest

J:231595 Gurdziel K, et al., Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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