About   Help   FAQ
Akap6
Gene Detail
Symbol

Name
ID
Akap6
A kinase (PRKA) anchor protein 6
MGI:3050566
Feature Type
protein coding gene
Genetic Map
Chromosome 12
22.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:52699383-53151015 bp, + strand
From Ensembl annotation of GRCm38

  451633 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3157  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AKAP6
Gene Tree: Akap6

Human
homologs
AKAP6, A kinase (PRKA) anchor protein 6
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9472
neXtProt AC: NX_Q13023

Human Synonyms: ADAP100, ADAP6, AKAP100, mAKAP, PRKA6

Human Chr (Location): 14q12; chr14:32329273-32833999 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted disruption of this gene results in partial embryonic lethality; surviving homozygotes display a decreased body weight, craniofacial defects and reduced viability.
 
Interactions
Akap6 interacts with 454 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process cellular protein complex localization, cellular response to cAMP, ...
Component calcium channel complex, caveola, ...
Function adenylate cyclase binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (141)    Tissues (45)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 141
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000061603 (Evidence)
Entrez Gene 238161 (Evidence)
DFCI TC1631010, TC1625266, TC1602619, TC1597699, TC1584605
DoTS DT.101261446, DT.101735925
NIA Mouse Gene Index U013944, U013946
Consensus CDS Project CCDS36444.1
International Mouse Phenotyping Consortium Status Akap6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061603 Ensembl Gene Model | MGI Sequence Detail 451633 C57BL/6J ±  kb
transcript ENSMUST00000095737 Ensembl | MGI Sequence Detail 10263 Not Applicable 
polypeptide ENSMUSP00000093406 Ensembl | MGI Sequence Detail 2307 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(18) UniProt(8)
Polymorphisms
SNPs within 2kb(5132 from dbSNP Build 137)    SNPs within 2kb including multiple locations(5146)
Protein-related
information
ResourceIDDescription
InterPro IPR026696 A-kinase anchor protein 6/Centrosomal protein of 68kDa
InterPro IPR018159 Spectrin/alpha-actinin
InterPro IPR002017 Spectrin repeat
Protein Ontology PR:000003893 A-kinase anchor protein 6
References
(Earliest) J:198914 Kapiloff MS, et al., mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope. J Cell Sci. 2001 Sep;114(Pt 17):3167-76
(Latest) J:214288 Kritzer MD, et al., The scaffold protein muscle A-kinase anchoring protein beta orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure. Circ Heart Fail. 2014 Jul;7(4):663-72
All references(34)
Other
accession IDs
MGI:2144849

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/30/2015
MGI 5.22
The Jackson Laboratory