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Akap6 Gene Detail
Summary
  • Symbol
    Akap6
  • Name
    A kinase (PRKA) anchor protein 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:3050566
    NCBI Gene: 238161
  • Gene Overview
    MyGene.info: AKAP6
Location & Maps
more
  • Sequence Map
    Chr12:52699383-53151015 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      451633 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 22.18 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    AKAP6, A-kinase anchoring protein 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AKAP6, A-kinase anchoring protein 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADAP100, ADAP6, AKAP100, mAKAP, PRKA6
  • Links
    NCBI Gene ID: 9472
    neXtProt AC: NX_Q13023

  • Chr Location
    14q12; chr14:32329273-32833999 (+)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 3157
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: AKAP6
  • Gene Tree
    Akap6
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 4 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Akap6
  • Incidental Mutations
    Mutagenetix , APF
Targeted disruption of this gene results in partial embryonic lethality; surviving homozygotes display a decreased body weight, craniofacial defects and reduced viability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    141
  • Tissues
    45
  • cDNA Data
    9
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061603 Ensembl Gene Model | MGI Sequence Detail 451633 C57BL/6J ±  kb
transcript ENSMUST00000095737 Ensembl | MGI Sequence Detail 10263 Not Applicable  
polypeptide ENSMUSP00000093406 Ensembl | MGI Sequence Detail 2307 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    5124 from dbSNP Build 142
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000003893 A-kinase anchor protein 6
  • InterPro Domains
    IPR026696 A-kinase anchor protein 6/Centrosomal protein of 68kDa
    IPR018159 Spectrin/alpha-actinin
    IPR002017 Spectrin repeat
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144849
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 6
  • Earliest
    J:198914 Kapiloff MS, et al., mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope. J Cell Sci. 2001 Sep;114(Pt 17):3167-76
  • Latest
    J:231595 Gurdziel K, et al., Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory