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Scube3 Gene Detail
Summary
  • Symbol
    Scube3
  • Name
    signal peptide, CUB domain, EGF-like 3
  • Synonyms
    D030038I21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045253
    NCBI Gene: 268935
Location & Maps
more
  • Sequence Map
    Chr17:28142316-28174852 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      32537 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 14.63 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SCUBE3, signal peptide, CUB domain and EGF like domain containing 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SCUBE3, signal peptide, CUB domain and EGF like domain containing 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CEGF3
  • Links
    NCBI Gene ID: 222663
    neXtProt AC: NX_Q8IX30

  • Chr Location
    6p21.31; chr6:35214047-35253079 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Mice homozygous for a targeted allele encoding a truncated protein exhibit normal morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021032 VEGA Gene Model | MGI Sequence Detail 32537 C57BL/6J ±  kb
transcript OTTMUST00000049724 VEGA | MGI Sequence Detail 6699 Not Applicable  
polypeptide OTTMUSP00000023089 VEGA | MGI Sequence Detail 993 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    230 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 2
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:226676 Lin YC, et al., Disruption of Scube2 Impairs Endochondral Bone Formation. J Bone Miner Res. 2015 Jul;30(7):1255-67

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory