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Symbol
Name
ID

Scube3
signal peptide, CUB domain, EGF-like 3
MGI:3045253

Phenotype annotations related to skeleton

Darker colors indicate more annotations

Human Phenotypes	Bicoronal synostosis	Microcephaly	Enamel hypoplasia	Brachydactyly	Short palm	Joint hypermobility	Joint stiffness	Short long bone	11 pairs of ribs	Scoliosis
Disease(s) Associated with SCUBE3
short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies

Mouse Phenotypes

abnormal temporal bone morphology

abnormal middle ear ossicle morphology

small incus

abnormal malleus morphology

abnormal malleus head morphology

small middle ear ossicles

fused phalanges

abnormal tarsal bone morphology

short femur

abnormal metacarpal bone morphology

abnormal metatarsal bone morphology

abnormal pectoral girdle bone morphology

rib fusion

abnormal thoracic vertebrae morphology

abnormal vertebral column morphology

kyphosis

abnormal lumbar vertebrae morphology

abnormal vertebral pedicle morphology

decreased bone mineral content

decreased bone mineral density

abnormal bone ossification

increased bone resorption

Availability

Mouse Genotype

Scube3^m1Btlr/Scube3^m1Btlr

Scube3^m1Mhda/Scube3^m1Mhda

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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