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Zic3
Gene Detail
 Symbol
Name
ID
Zic3
zinc finger protein of the cerebellum 3
MGI:106676
Synonyms Ka
Feature Type protein coding gene
Genetic Map
Chromosome X
32.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)
Sequence Map
ChrX:58022700-58041736 bp, + strand
From VEGA annotation of GRCm38

  19037 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55742  Vertebrate Homology Class
1 human; 1 mouse; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Zic3

Human
homologs
Human Homolog ZIC3, Zic family member 3
NCBI Gene ID 7547
neXtProt AC  NX_O60481
Human Synonyms  HTX, HTX1, VACTERLX, ZNF203
Human Chr (Location)  Xq26.2; chrX:137566187-137572100 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human ZIC3
Mutations,
alleles, and
phenotypes
All mutations/alleles(43) : Gene trapped(33) Spontaneous(2) Targeted(8)
Incidental mutations (data from APF )
 
Mutants show incomplete penetrance varying by genetic background and allele. Phenotypes range from bent tail/skeletal abnormalities to severe defects in embryo turning, cardiac development and neural tube closure resulting in death at embryonic day 18.5
 
Human Diseases Modeled Using Mouse Zic3 (2)    Alleles Annotated to Human Diseases(3)   
Interactions
Zic3 interacts with 357 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process anterior/posterior pattern specification, cell differentiation, ...
Component cytoplasm, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (37 records)
Data Summary: Results (382)    Tissues (267)    Images (59)
Theiler Stages: 2, 3, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 309
In situ reporter (knock in) 1
Northern blot 1
RT-PCR 47
RNase protection 24
cDNA source data(27)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) Genomic(2) cDNA(28) Primer pair(5) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000017528 (Evidence)
Ensembl Gene ModelENSMUSG00000067860 (Evidence)
Entrez Gene22773 (Evidence)
UniGene255890
DFCITC1582638, TC1588896, TC1633550
DoTSDT.101344050, DT.50316029, DT.55163466, DT.99841158
NIA Mouse Gene IndexU043760
Consensus CDS ProjectCCDS30155.1
International Mouse Knockout Project StatusZic3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017528 VEGA Gene Model | MGI Sequence Detail 19037 C57BL/6J ±  kb
transcript OTTMUST00000042579 VEGA | MGI Sequence Detail 3949 Not Applicable 
polypeptide OTTMUSP00000019133 VEGA | MGI Sequence Detail 466 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(18) UniProt(5)
Polymorphisms PCR(1) : SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017667 zinc finger protein ZIC 3
References (Earliest) J:13124 Garber ED, 'Bent-Tail,' A Dominant, Sex-Linked Mutation in the Mouse. Proc Natl Acad Sci U S A. 1952 Oct;38(10):876-9
(Latest) J:199302 Veenvliet JV, et al., Specification of dopaminergic subsets involves interplay of En1 and Pitx3. Development. 2013 Aug;140(16):3373-84
All references(100)
Disease annotation references (7)
Other
accession IDs
MGD-MRK-1607, MGD-MRK-35135, MGI:3043027, MGI:88185

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory