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Prex1 Gene Detail
Summary
  • Symbol
    Prex1
  • Name
    phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
  • Synonyms
    P-REX1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3040696
    NCBI Gene: 277360
  • Gene Overview
    MyGene.info: PREX1
Location & Maps
more
  • Sequence Map
    Chr2:166566342-166713832 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      147491 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PREX1, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PREX1, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    P-REX1
  • Links
    NCBI Gene ID: 57580
    neXtProt AC: NX_Q8TCU6

  • Chr Location
    20q13.13; chr20:48624249-48827883 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    2 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele have impaired neutrophil migration. Mice with other alleles exhibit reduced weight, smaller livers and increased peripheral neutrophil numbers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001160 VEGA Gene Model | MGI Sequence Detail 147491 C57BL/6J ±  kb
transcript OTTMUST00000002256 VEGA | MGI Sequence Detail 6533 Not Applicable  
polypeptide OTTMUSP00000001101 VEGA | MGI Sequence Detail 1650 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    997 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000013202 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
  • InterPro Domains
    IPR000219 Dbl homology (DH) domain
    IPR000591 DEP domain
    IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
    IPR001478 PDZ domain
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 8
    cDNA 7
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:221504 Pan D, et al., P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation. Blood. 2015 Feb 12;125(7):1146-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory