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Prex1
Gene Detail
Symbol

Name
ID
Prex1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
MGI:3040696
Synonyms
P-REX1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
87.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:166566342-166713832 bp, - strand
From VEGA annotation of GRCm38

  147491 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10821  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PREX1
Protein SuperFamily: phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger protein
Gene Tree: Prex1

Human
homologs
PREX1, phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 57580
neXtProt AC: NX_Q8TCU6

Human Synonyms: P-REX1

Human Chr (Location): 20q13.13; chr20:48624249-48827883 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele have impaired neutrophil migration. Mice with other alleles exhibit reduced weight, smaller livers and increased peripheral neutrophil numbers.
 
Phenotype Images(2)
Interactions
Prex1 interacts with 220 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process G-protein coupled receptor signaling pathway, intracellular signal transduction, ...
Component cytoplasm, cytosol, ...
Function guanyl-nucleotide exchange factor activity, phospholipid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (231)    Tissues (69)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 218
Northern blot 6
Western blot 2
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PREX1 ; Xenbase prex1    NEW 
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000001160 (Evidence)
Ensembl Gene Model ENSMUSG00000039621 (Evidence)
Entrez Gene 277360 (Evidence)
DFCI TC1624310, TC1601610, TC1580024
NIA Mouse Gene Index U023668
Consensus CDS Project CCDS38334.1
International Mouse Phenotyping Consortium Status Prex1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001160 VEGA Gene Model | MGI Sequence Detail 147491 C57BL/6J ±  kb
transcript OTTMUST00000002256 VEGA | MGI Sequence Detail 6533 Not Applicable 
polypeptide OTTMUSP00000001101 VEGA | MGI Sequence Detail 1650 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(1000 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR000591 DEP domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001478 PDZ domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000013202 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:221504 Pan D, et al., P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation. Blood. 2015 Feb 12;125(7):1146-58
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory