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Prex1 Gene Detail
Summary
  • Symbol
    Prex1
  • Name
    phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
  • Synonyms
    P-REX1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3040696
    NCBI Gene: 277360
  • Gene Overview
    MyGene.info: PREX1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:166566345-166713832 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 87.09 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    997 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3040696
protein coding gene Chr2:166566342-166713832 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026901
protein coding gene Chr2:172222794-172378024 (-)
A/J MGP_AJ_G0026867
protein coding gene Chr2:165158706-165308342 (-)
AKR/J MGP_AKRJ_G0026840
protein coding gene Chr2:170078600-170224746 (-)
BALB/cJ MGP_BALBcJ_G0026876
protein coding gene Chr2:165514124-165661490 (-)
C3H/HeJ MGP_C3HHeJ_G0026620
protein coding gene Chr2:170435426-170586328 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027324
protein coding gene Chr2:177229495-177387951 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024696
protein coding gene Chr2:158502991-158652052 (-)
CAST/EiJ MGP_CASTEiJ_G0026078
protein coding gene Chr2:170879061-171045382 (-)
CBA/J MGP_CBAJ_G0026597
protein coding gene Chr2:183716287-183880244 (-)
DBA/2J MGP_DBA2J_G0026733
protein coding gene Chr2:164291121-164440352 (-)
FVB/NJ MGP_FVBNJ_G0026701
protein coding gene Chr2:162787926-162938319 (-)
LP/J MGP_LPJ_G0026835
protein coding gene Chr2:172254159-172416111 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026720
protein coding gene Chr2:187141336-187295825 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027380
protein coding gene Chr2:169976713-170128423 (-)
PWK/PhJ MGP_PWKPhJ_G0025813
protein coding gene Chr2:163920913-164073098 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025615
protein coding gene Chr2:168908863-169082653 (-)
WSB/EiJ MGP_WSBEiJ_G0026149
protein coding gene Chr2:170887487-171039517 (-)



Homology
more
  • Human Ortholog
    PREX1, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PREX1, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    P-REX1
  • Links
    NCBI Gene ID: 57580
    neXtProt AC: NX_Q8TCU6
    UniProt: Q8TCU6

  • Chr Location
    20q13.13; chr20:48624252-48827883 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Prex1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    2 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele have impaired neutrophil migration and autism-like social behavior with defective AMPA-mediated LTD. Mice with other alleles exhibit reduced weight, smaller livers and increased peripheral neutrophil numbers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 277360 NCBI Gene Model | MGI Sequence Detail 147488 C57BL/6J ±  kb
    transcript NM_177782 RefSeq | MGI Sequence Detail 6530 Not Specified  
    polypeptide Q69ZK0 UniProt | EBI | MGI Sequence Detail 1650 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:235644 Wu Y, et al., Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. PLoS Genet. 2016 Sep;12(9):e1006355

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory