About   Help   FAQ
Vtcn1 Gene Detail
Summary
  • Symbol
    Vtcn1
  • Name
    V-set domain containing T cell activation inhibitor 1
  • Synonyms
    B7-H4, B7x
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039619
    NCBI Gene: 242122
  • Gene Overview
    MyGene.info: VTCN1
Location & Maps
more
  • Sequence Map
    Chr3:100825459-100896922 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      71464 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 43.78 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    VTCN1, V-set domain containing T cell activation inhibitor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VTCN1, V-set domain containing T cell activation inhibitor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    B7H4, B7-H4, B7h.5, B7S1, B7X, PRO1291, VCTN1
  • Links
    NCBI Gene ID: 79679
    neXtProt AC: NX_Q7Z7D3

  • Chr Location
    1p13.1; chr1:117143587-117270368 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11627
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: VTCN1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 4 genetic backgrounds
    9 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    2 involving Vtcn1
  • Incidental Mutations
    APF
Mice homozygous for this mutation display stronger Th1 responses upon parasitic infection by L. major including reduced footpad swelling and lower parasite burden compared to controls. Responses to other Th1-driven immune responses are normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007078 VEGA Gene Model | MGI Sequence Detail 71464 C57BL/6J ±  kb
transcript OTTMUST00000016375 VEGA | MGI Sequence Detail 2622 Not Applicable  
polypeptide OTTMUSP00000007490 VEGA | MGI Sequence Detail 283 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    681 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000017357 V-set domain-containing T-cell activation inhibitor 1
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR003598 Immunoglobulin subtype 2
    IPR013106 Immunoglobulin V-set domain
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:94876 Zang X, et al., B7x: a widely expressed B7 family member that inhibits T cell activation. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10388-92
  • Latest
    J:204842 Leung J, et al., Host B7-H4 regulates antitumor T cell responses through inhibition of myeloid-derived suppressor cells in a 4T1 tumor transplantation model. J Immunol. 2013 Jun 15;190(12):6651-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory