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Slc13a5 Gene Detail
Summary
  • Symbol
    Slc13a5
  • Name
    solute carrier family 13 (sodium-dependent citrate transporter), member 5
  • Synonyms
    Indy, mINDY, NaC2/NaCT, Nact
  • Feature Type
    protein coding gene
  • IDs
    MGI:3037150
    NCBI Gene: 237831
  • Gene Overview
    MyGene.info: SLC13A5
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:72241990-72267056 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 43.95 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    100 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3037150
protein coding gene Chr11:72241989-72267222 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018634
protein coding gene Chr11:72860020-72885356 (-)
A/J MGP_AJ_G0018602
protein coding gene Chr11:70134454-70161471 (-)
AKR/J MGP_AKRJ_G0018571
protein coding gene Chr11:72268604-72297973 (-)
BALB/cJ MGP_BALBcJ_G0018574
protein coding gene Chr11:70429898-70454781 (-)
C3H/HeJ MGP_C3HHeJ_G0018387
protein coding gene Chr11:72230175-72256032 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019025
protein coding gene Chr11:75063972-75089316 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016668
protein coding gene Chr11:66976346-67000939 (-)
CAST/EiJ MGP_CASTEiJ_G0017942
protein coding gene Chr11:72578778-72626264 (-)
CBA/J MGP_CBAJ_G0018359
protein coding gene Chr11:78386978-78414088 (-)
DBA/2J MGP_DBA2J_G0018468
protein coding gene Chr11:69784440-69809568 (-)
FVB/NJ MGP_FVBNJ_G0018459
protein coding gene Chr11:69308452-69333663 (-)
LP/J MGP_LPJ_G0018539
protein coding gene Chr11:73368686-73393605 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018482
protein coding gene Chr11:78959528-78984800 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019067
protein coding gene Chr11:72473946-72498875 (-)
PWK/PhJ MGP_PWKPhJ_G0017715
protein coding gene Chr11:70396740-70422313 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017505
protein coding gene Chr11:72179029-72204566 (-)
WSB/EiJ MGP_WSBEiJ_G0017996
protein coding gene Chr11:72210627-72235973 (-)



Homology
more
  • Human Ortholog
    SLC13A5, solute carrier family 13 member 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC13A5, solute carrier family 13 member 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EIEE25, INDY, mIndy, NACT
  • Links
    NCBI Gene ID: 284111
    neXtProt AC: NX_Q86YT5
    UniProt: Q86YT5

  • Chr Location
    17p13.1; chr17:6684713-6713421 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display resistance to diet and age induced obesity, increased energy expenditure, improved glucose tolerance, and increased hepatic lipid oxidation. Mice homozygous for an ENU-induced allele exhibit reduced body weight.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 237831 NCBI Gene Model | MGI Sequence Detail 25067 C57BL/6J ±  kb
    transcript NM_001004148 RefSeq | MGI Sequence Detail 3285 C57BL/6  
    polypeptide Q67BT3 UniProt | EBI | MGI Sequence Detail 572 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 14
      Primer pair 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:245180 Irizarry AR, et al., Defective enamel and bone development in sodium-dependent citrate transporter (NaCT) Slc13a5 deficient mice. PLoS One. 2017;12(4):e0175465

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory