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Fhip2b Gene Detail
Summary
  • Symbol
    Fhip2b
  • Name
    FHF complex subunit HOOK interacting protein 2B
  • Synonyms
    Fam160b2, G430067P06Rik, Rai16
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036290
    NCBI Gene: 239170
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:70820736-70837275 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 36.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3036290
protein coding gene Chr14:70820733-70837309 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021545
protein coding gene Chr14:65241308-65259555 (-)
A/J MGP_AJ_G0021504
protein coding gene Chr14:63852520-63868971 (-)
AKR/J MGP_AKRJ_G0021480
protein coding gene Chr14:65765323-65783728 (-)
BALB/cJ MGP_BALBcJ_G0021510
protein coding gene Chr14:63615514-63632030 (-)
C3H/HeJ MGP_C3HHeJ_G0021287
protein coding gene Chr14:65480313-65497742 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021949
protein coding gene Chr14:68152365-68169715 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019489
protein coding gene Chr14:61689231-61705998 (-)
CAST/EiJ MGP_CASTEiJ_G0020804
protein coding gene Chr14:62078133-62094904 (-)
CBA/J MGP_CBAJ_G0021254
protein coding gene Chr14:70299183-70320305 (-)
DBA/2J MGP_DBA2J_G0021377
protein coding gene Chr14:63237184-63253877 (-)
FVB/NJ MGP_FVBNJ_G0021356
protein coding gene Chr14:62666472-62683300 (-)
LP/J MGP_LPJ_G0021448
protein coding gene Chr14:66480968-66500242 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021385
protein coding gene Chr14:69179896-69197341 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021973
protein coding gene Chr14:65027553-65046123 (-)
PWK/PhJ MGP_PWKPhJ_G0020548
protein coding gene Chr14:60006398-60023069 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020381
protein coding gene Chr14:60956455-60972636 (-)
WSB/EiJ MGP_WSBEiJ_G0020857
protein coding gene Chr14:65341459-65358947 (-)



Homology
more
  • Human Ortholog
    FHIP2B, FHF complex subunit HOOK interacting protein 2B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FHIP2B, FHF complex subunit HOOK interacting protein 2B
  • Synonyms
    FAM160B2, RAI16
  • Links
    NCBI Gene ID: 64760
    neXtProt AC: NX_Q86V87
    UniProt: Q86V87

  • Chr Location
    8p21.3; chr8:22089150-22104380 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mice expressing a protein lacking exon 3 show increased susceptibility to induced colitis and colitis-associated colorectal cancer. Mice show an increase in bacailli and decrease in A. muciniphila in the microflora and exacerbated high-fat diet-induced steatohepatitis.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022095 Ensembl Gene Model | MGI Sequence Detail 16540 C57BL/6J ±  kb
    transcript ENSMUST00000022690 Ensembl | MGI Sequence Detail 4033 Not Applicable  
    polypeptide ENSMUSP00000022690 Ensembl | MGI Sequence Detail 744 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000032178 FHF complex subunit HOOK interacting protein 2B
    • InterPro Domains
      IPR019384 FHF complex subunit HOOK interacting protein
      IPR045669 FHF complex subunit HOOK interacting protein, C-terminal
      IPR045668 FHF complex subunit HOOK interacting protein, KELAA motif
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9
    References
    more
    • Summaries
      All 27
      Phenotypes 14
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:302658 Qian CL, et al., Retinoic acid induced 16 deficiency exacerbates high-fat diet-induced steatohepatitis in mice. Cell Biochem Funct. 2020 Aug;38(6):753-760

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    08/09/2022
    MGI 6.21
    The Jackson Laboratory