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Tmtc3 Gene Detail
Summary
  • Symbol
    Tmtc3
  • Name
    transmembrane and tetratricopeptide repeat containing 3
  • Synonyms
    9130014E20Rik, B130008E12Rik, mSmile
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036255
    NCBI Gene: 237500
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:100443902-100487350 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 51.47 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    513 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3036255
 protein coding gene Chr10:100443902-100487365 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017690
 protein coding gene Chr10:102310285-102352329 (-)
A/J MGP_AJ_G0017669
 protein coding gene Chr10:98596403-98640019 (-)
AKR/J MGP_AKRJ_G0017631
 protein coding gene Chr10:101416137-101464581 (-)
BALB/cJ MGP_BALBcJ_G0017633
 protein coding gene Chr10:98903967-98946444 (-)
C3H/HeJ MGP_C3HHeJ_G0017458
 protein coding gene Chr10:101442773-101491272 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018090
 protein coding gene Chr10:105868641-105926397 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015769
 protein coding gene Chr10:93979834-94022962 (-)
CAST/EiJ MGP_CASTEiJ_G0017019
 protein coding gene Chr10:101488593-101534919 (-)
CBA/J MGP_CBAJ_G0017427
 protein coding gene Chr10:109961883-110008078 (-)
DBA/2J MGP_DBA2J_G0017532
 protein coding gene Chr10:97684052-97725598 (-)
FVB/NJ MGP_FVBNJ_G0017526
 protein coding gene Chr10:96881080-96926650 (-)
LP/J MGP_LPJ_G0017606
 protein coding gene Chr10:102926451-102970550 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017556
 protein coding gene Chr10:111232552-111297220 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018128
 protein coding gene Chr10:101370873-101437984 (-)
PWK/PhJ MGP_PWKPhJ_G0016801
 protein coding gene Chr10:97753806-97796352 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016591
 protein coding gene Chr10:100173232-100216199 (-)
WSB/EiJ MGP_WSBEiJ_G0017079
 protein coding gene Chr10:101372906-101421532 (-)



Homology
more
  • Human Ortholog
    TMTC3, transmembrane O-mannosyltransferase targeting cadherins 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TMTC3, transmembrane O-mannosyltransferase targeting cadherins 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LIS8, SMILE
  • Links
    NCBI Gene ID: 160418
    neXtProt AC: NX_Q6ZXV5
    UniProt: Q6ZXV5

  • Chr Location
    12q21.32; chr12:88142296-88199887 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human TMTC3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit impaired bronchial smooth muscle and alveolar myofibroblast development that leads to cyanosis and postnatal lethality in some mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    687
  • Tissues
    22
  • cDNA Data
    52
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036676 Ensembl Gene Model | MGI Sequence Detail 43449 C57BL/6J ±  kb
    transcript ENSMUST00000058154 Ensembl | MGI Sequence Detail 5993 Not Applicable  
    polypeptide ENSMUSP00000061470 Ensembl | MGI Sequence Detail 920 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 52
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1918840
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 16
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:178869 Yun EJ, et al., mSmile is Necessary for Bronchial Smooth Muscle and Alveolar Myofibroblast Development. Anat Rec (Hoboken). 2012 Jan;295(1):167-76
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/06/2021
    MGI 6.16     		The Jackson Laboratory