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Lrrc4b Gene Detail
Summary
  • Symbol
    Lrrc4b
  • Name
    leucine rich repeat containing 4B
  • Synonyms
    Lrig4, Ngl3, NGL-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3027390
    NCBI Gene: 272381
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44091911-44112775 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    91 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3027390
protein coding gene Chr7:44078442-44112775 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032161
protein coding gene Chr7:44600147-44634059 (+)
A/J MGP_AJ_G0032140
protein coding gene Chr7:43782998-43818720 (+)
AKR/J MGP_AKRJ_G0032076
protein coding gene Chr7:44985187-45021204 (+)
BALB/cJ MGP_BALBcJ_G0032152
protein coding gene Chr7:43779679-43815128 (+)
C3H/HeJ MGP_C3HHeJ_G0031868
protein coding gene Chr7:45475357-45512409 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032644
protein coding gene Chr7:46848470-46890036 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029658
protein coding gene Chr7:46371615-46404604 (+)
CAST/EiJ MGP_CASTEiJ_G0031196
protein coding gene Chr7:36845521-36887535 (+)
CBA/J MGP_CBAJ_G0031832
protein coding gene Chr7:48375773-48413256 (+)
DBA/2J MGP_DBA2J_G0031990
protein coding gene Chr7:43458222-43492881 (+)
FVB/NJ MGP_FVBNJ_G0031941
protein coding gene Chr7:43188990-43225897 (+)
LP/J MGP_LPJ_G0032068
protein coding gene Chr7:45278556-45316341 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031978
protein coding gene Chr7:47127065-47162959 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032660
protein coding gene Chr7:44201895-44235671 (+)
PWK/PhJ MGP_PWKPhJ_G0030919
protein coding gene Chr7:36801248-36837813 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030756
protein coding gene Chr7:32209892-32245488 (+)
WSB/EiJ MGP_WSBEiJ_G0031313
protein coding gene Chr7:44662830-44698212 (+)



Homology
more
  • Human Ortholog
    LRRC4B, leucine rich repeat containing 4B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRC4B, leucine rich repeat containing 4B
  • Synonyms
    HSM, LRIG4, NGL-3
  • Links
    NCBI Gene ID: 94030
    neXtProt AC: NX_Q9NT99
    UniProt: Q9NT99

  • Chr Location
    19q13.33; chr19:50516892-50568435 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 2 alleles in 3 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired brain development and impaired long-term depression, and locomotive and cognitive behaviors in a background strain manner.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 272381 NCBI Gene Model | MGI Sequence Detail 20865 C57BL/6J ±  kb
    transcript NM_198250 RefSeq | MGI Sequence Detail 2753 C57BL/6  
    polypeptide P0C192 UniProt | EBI | MGI Sequence Detail 709 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 28
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 3
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:276446 Lee H, et al., NGL-3 in the regulation of brain development, Akt/GSK3b signaling, long-term depression, and locomotive and cognitive behaviors. PLoS Biol. 2019 Jun;17(6):e2005326

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory