About   Help   FAQ
Trim71 Gene Detail
Summary
  • Symbol
    Trim71
  • Name
    tripartite motif-containing 71
  • Synonyms
    2610206G21Rik, 636931, lin-41, Lin41, LOC382112, mlin-41, mLin41
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685973
    NCBI Gene: 636931
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:114507133-114564369 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      57237 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 64.54 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TRIM71, tripartite motif containing 71
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TRIM71, tripartite motif containing 71
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LIN41, LIN-41
  • Links
    NCBI Gene ID: 131405
    neXtProt AC: NX_Q2Q1W2
    UniProt: Q2Q1W2

  • Chr Location
    3p22.3; chr3:32818018-32897826 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9076
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TRIM71
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 4 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous gene trap mutations of this gene result in failure of cranial neural tube closure and embryonic lethality. Homozygotes for a gene trap allele exhibit exencephaly, abnormal nasal process and facial prominence, reduced brain size, and embryonic or fetal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000044351 VEGA Gene Model | MGI Sequence Detail 57237 C57BL/6J ±  kb
    transcript OTTMUST00000116728 VEGA | MGI Sequence Detail 9332 Not Applicable  
    polypeptide OTTMUSP00000065111 VEGA | MGI Sequence Detail 855 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      254 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1919741, MGI:2143176, MGI:3779694
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 12
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:255059 Nguyen DTT, et al., The ubiquitin ligase LIN41/TRIM71 targets p53 to antagonize cell death and differentiation pathways during stem cell differentiation. Cell Death Differ. 2017 Jun;24(6):1063-1078

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory