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Cracr2a Gene Detail
Summary
  • Symbol
    Cracr2a
  • Name
    calcium release activated channel regulator 2A
  • Synonyms
    Efcab4b, LOC243645, LOC381812
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685919
    NCBI Gene: 381812
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:127561064-127673733 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 62.39 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    551 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685919
protein coding gene Chr6:127561064-127674248 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031315
protein coding gene Chr6:131086093-131161185 (+)
A/J MGP_AJ_G0031286
protein coding gene Chr6:126082783-126151846 (+)
AKR/J MGP_AKRJ_G0031214
protein coding gene Chr6:129487331-129556976 (+)
BALB/cJ MGP_BALBcJ_G0031293
protein coding gene Chr6:125639608-125709428 (+)
C3H/HeJ MGP_C3HHeJ_G0031017
protein coding gene Chr6:129626117-129698000 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031750
protein coding gene Chr6:134506290-134587065 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028898
protein coding gene Chr6:123256449-123325909 (+)
CAST/EiJ MGP_CASTEiJ_G0030398
protein coding gene Chr6:129847172-129921161 (+)
CBA/J MGP_CBAJ_G0030978
protein coding gene Chr6:139667420-139756729 (+)
DBA/2J MGP_DBA2J_G0031134
protein coding gene Chr6:124970953-125039897 (+)
FVB/NJ MGP_FVBNJ_G0031083
protein coding gene Chr6:123893232-123961886 (+)
LP/J MGP_LPJ_G0031214
protein coding gene Chr6:131178420-131253491 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031122
protein coding gene Chr6:143598785-143670854 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031785
protein coding gene Chr6:129460869-129533211 (+)
PWK/PhJ MGP_PWKPhJ_G0030113
protein coding gene Chr6:123249591-123322016 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029942
protein coding gene Chr6:127550230-127631638 (+)
WSB/EiJ MGP_WSBEiJ_G0030483
protein coding gene Chr6:129825432-129904593 (+)



Homology
more
  • Human Ortholog
    CRACR2A, calcium release activated channel regulator 2A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRACR2A, calcium release activated channel regulator 2A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EFCAB4B
  • Links
    NCBI Gene ID: 84766
    neXtProt AC: NX_Q9BSW2
    UniProt: Q9BSW2

  • Chr Location
    12p13.32; chr12:3613366-3753216 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 381812 NCBI Gene Model | MGI Sequence Detail 112670 C57BL/6J ±  kb
transcript NM_001033464 RefSeq | MGI Sequence Detail 1094 C57BL/6  
polypeptide Q3UP38 UniProt | EBI | MGI Sequence Detail 310 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 1
Other
Accession IDs
less
MGI:2685308
References
more
  • Summaries
    All 21
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:264324 Woo JS, et al., CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses. J Immunol. 2018 Aug 15;201(4):1174-1185

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory