About   Help   FAQ
Drc1
Gene Detail
Symbol

Name
ID
Drc1
dynein regulatory complex subunit 1
MGI:2685906
Synonyms
b2b1654Clo, Ccdc164, Gm1060, LOC381738
Feature Type
protein coding gene
Genetic Map
Chromosome 5
16.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:30281388-30366695 bp, + strand
From VEGA annotation of GRCm38

  85308 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:35977  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DRC1
Gene Tree: Drc1

Human
homologs
DRC1, dynein regulatory complex subunit 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 92749
neXtProt AC: NX_Q96MC2

Human Synonyms: C2orf39, CCDC164, CILD21

Human Chr (Location): 2p23.3; chr2:26401916-26456713 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DRC1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(2) Radiation induced(4)
Genomic Mutations involving Drc1 (4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for ENU-induced mutations exhibit heterotaxy with complex congenital heart disease such as transposition of the great arteries (TGA), atrioventricular septal defects (AVSD), and vein abnormalities; immotile/dyskinetic airway cilia are also seen.
 
Human Diseases Modeled in Mice Using Drc1 (1)    Mutations Annotated to Human Diseases (3)    Phenotype Images(32)
Interactions
Drc1 interacts with 42 markers (Mir96, Mir136, Mir149, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process axonemal dynein complex assembly, bacterial-type flagellum-dependent cell motility, ...
Component cell projection, cilium, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (37)    Tissues (5)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 37
cDNA source data(3)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase drc1    NEW 
Molecular
reagents
All nucleic(3) cDNA(3)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000054792 (Evidence)
Ensembl Gene Model ENSMUSG00000073102 (Evidence)
Entrez Gene 381738 (Evidence)
DFCI TC1583987
DoTS DT.111111695, DT.482196
NIA Mouse Gene Index U005416
International Mouse Phenotyping Consortium Status Drc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054792 VEGA Gene Model | MGI Sequence Detail 85308 C57BL/6J ±  kb
transcript OTTMUST00000135771 VEGA | MGI Sequence Detail 2471 Not Applicable 
polypeptide OTTMUSP00000071784 VEGA | MGI Sequence Detail 753 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(103 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR029440 Dynein regulatory complex protein 1, C-terminal
Protein Ontology PR:000031828 coiled-coil domain-containing protein 164
References
(Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:222159 Li Y, et al., Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28;521(7553):520-4
All references(22)
Disease annotation references (1)
Other
accession IDs
MGI:5438047

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory