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Drc1 Gene Detail
Summary
  • Symbol
    Drc1
  • Name
    dynein regulatory complex subunit 1
  • Synonyms
    b2b1654Clo, Ccdc164, Gm1060, LOC381738
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685906
    NCBI Gene: 381738
Location & Maps
more
  • Sequence Map
    Chr5:30281388-30366695 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      85308 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 16.42 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DRC1, dynein regulatory complex subunit 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DRC1, dynein regulatory complex subunit 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C2orf39, CCDC164, CILD21
  • Links
    NCBI Gene ID: 92749
    neXtProt AC: NX_Q96MC2

  • Chr Location
    2p23.3; chr2:26401916-26456713 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 35977
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DRC1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Drc1 mouse models; 1 with human DRC1 associations

Human Disease Mouse Models
       Ciliary Dyskinesia, Primary, 21; CILD21   OMIM: 615294 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    28 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    2
  • Radiation induced
    4
  • Spontaneous
    1
  • Genomic Mutations
    7 involving Drc1
  • Incidental Mutations
Mice homozygous for ENU-induced mutations exhibit heterotaxy with complex congenital heart disease such as transposition of the great arteries (TGA), atrioventricular septal defects (AVSD), and vein abnormalities; immotile/dyskinetic airway cilia are also seen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054792 VEGA Gene Model | MGI Sequence Detail 85308 C57BL/6J ±  kb
transcript OTTMUST00000135771 VEGA | MGI Sequence Detail 2471 Not Applicable  
polypeptide OTTMUSP00000071784 VEGA | MGI Sequence Detail 753 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    101 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000031828 coiled-coil domain-containing protein 164
  • InterPro Domains
    IPR029440 Dynein regulatory complex protein 1, C-terminal
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 2
Other
Accession IDs
less
MGI:5438047
References
more
  • Summaries
    All 19
    Developmental Gene Expression 1
    Diseases 2
    Gene Ontology 3
    Phenotypes 23
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:222159 Li Y, et al., Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28;521(7553):520-4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory