About   Help   FAQ
Parp4 Gene Detail
Summary
  • Symbol
    Parp4
  • Name
    poly (ADP-ribose) polymerase family, member 4
  • Synonyms
    Adprtl1, C030027K23Rik, E230037B21Rik, p193, PH5P, VAULT3, VPARP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685589
    NCBI Gene: 328417
  • Gene Overview
    MyGene.info: PARP4
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56575619-56659794 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    540 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685589
protein coding gene Chr14:56575619-56659798 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021395
protein coding gene Chr14:50666894-50753488 (+)
A/J MGP_AJ_G0021354
protein coding gene Chr14:49660452-49744615 (+)
AKR/J MGP_AKRJ_G0021330
protein coding gene Chr14:51459604-51544875 (+)
BALB/cJ MGP_BALBcJ_G0021357
protein coding gene Chr14:49651275-49735316 (+)
C3H/HeJ MGP_C3HHeJ_G0021138
protein coding gene Chr14:51103638-51188751 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021797
protein coding gene Chr14:53196763-53282781 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019339
protein coding gene Chr14:47815812-47902733 (+)
CAST/EiJ MGP_CASTEiJ_G0020657
protein coding gene Chr14:47426273-47513148 (+)
CBA/J MGP_CBAJ_G0021105
protein coding gene Chr14:54776526-54864140 (+)
DBA/2J MGP_DBA2J_G0021225
protein coding gene Chr14:49376975-49461189 (+)
FVB/NJ MGP_FVBNJ_G0021208
protein coding gene Chr14:48765565-48854384 (+)
LP/J MGP_LPJ_G0021300
protein coding gene Chr14:51735787-51823752 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021232
protein coding gene Chr14:54170492-54258195 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021823
protein coding gene Chr14:50588276-50679902 (+)
PWK/PhJ MGP_PWKPhJ_G0020400
protein coding gene Chr14:45897102-45983264 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020230
protein coding gene Chr14:46655478-46743101 (+)
WSB/EiJ MGP_WSBEiJ_G0020709
protein coding gene Chr14:50925869-51016829 (+)



Homology
more
  • Human Ortholog
    PARP4, poly(ADP-ribose) polymerase family member 4
  • Vertebrate Orthologs
    14
  • Human Ortholog
    PARP4, poly(ADP-ribose) polymerase family member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADPRTL1, ARTD4, p193, PARP-4, PARPL, PH5P, VAULT3, VPARP, VWA5C
  • Links
    NCBI Gene ID: 143
    neXtProt AC: NX_Q9UKK3
    UniProt: Q9UKK3

  • Chr Location
    13q12.12; chr13:24420930-24512993 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 124423
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;5 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PARP4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    8 phenotype references
Homozygous null mutants are helathy and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054509 Ensembl Gene Model | MGI Sequence Detail 84176 C57BL/6J ±  kb
transcript ENSMUST00000161553 Ensembl | MGI Sequence Detail 6387 Not Applicable  
polypeptide ENSMUSP00000124258 Ensembl | MGI Sequence Detail 1969 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 23

    Microarray probesets 2
Other
Accession IDs
less
MGI:1924669
References
more
  • Summaries
    All 31
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:171050 Thiagarajan RD, et al., Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. PLoS One. 2011;6(2):e17286

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory