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Rc3h1
Gene Detail
Symbol

Name
ID
Rc3h1
RING CCCH (C3H) domains 1
MGI:2685397
Synonyms
5730557L09Rik, roquin
Feature Type
protein coding gene
Genetic Map
Chromosome 1
69.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:160906418-160974978 bp, + strand
From VEGA annotation of GRCm38

  68561 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:19036  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rc3h1

Human
homologs
Human Homolog RC3H1, ring finger and CCCH-type domains 1
NCBI Gene ID 149041
neXtProt AC  NX_Q5TC82
Human Synonyms  RNF198, ROQUIN
Human Chr (Location)  1q25.1; chr1:173919053-173993072 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Chemically induced (ENU)(1) Gene trapped(6) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
A single recessive mutation on this gene resulted in severe autoimmune disease with phenotype resembling human systemic lupus erythematosus.
 
Human Diseases Modeled Using Mouse Rc3h1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(6)
Interactions
Rc3h1 interacts with 535 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process B cell homeostasis, cytoplasmic mRNA processing body assembly, ...
Component cytoplasm, cytoplasmic mRNA processing body, ...
Function metal ion binding, mRNA 3'-UTR binding, ...
External Resources: FuncBase
Expression
cDNA source data(68)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(69) cDNA(68) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000034799 (Evidence)
Ensembl Gene ModelENSMUSG00000040423 (Evidence)
Entrez Gene381305 (Evidence)
UniGene329667
DFCITC1623142, TC1720870, TC1721734, TC1586093
DoTSDT.55271889, DT.99760914, DT.101327604, DT.101233520
NIA Mouse Gene IndexU000988
PDB4QI0, 4QI2
Consensus CDS ProjectCCDS15410.1
International Mouse Knockout Project StatusRc3h1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034799 VEGA Gene Model | MGI Sequence Detail 68561 C57BL/6J ±  kb
transcript OTTMUST00000088460 VEGA | MGI Sequence Detail 11006 Not Applicable 
polypeptide OTTMUSP00000048205 VEGA | MGI Sequence Detail 1130 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(5) UniProt(7)
Polymorphisms
SNPs within 2kb(325 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000571 Zinc finger, CCCH-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000013828 roquin
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:213226 Montufar-Solis D, et al., Hematopoietic not systemic impairment of Roquin expression accounts for intestinal inflammation in Roquin-deficient mice. Sci Rep. 2014;4:4920
All references(54)
Disease annotation references (1)
Other
accession IDs
MGI:1917908, MGI:2138726

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory