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Akap5 Gene Detail
Summary
  • Symbol
    Akap5
  • Name
    A kinase (PRKA) anchor protein 5
  • Synonyms
    3526401B18Rik, AKAP150, LOC238276
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685104
    NCBI Gene: 238276
  • Gene Overview
    MyGene.info: AKAP5
Location & Maps
more
  • Sequence Map
    Chr12:76324891-76334153 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9263 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 33.73 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    AKAP5, A-kinase anchoring protein 5
  • Vertebrate Orthologs
    7
  • Human Ortholog
    AKAP5, A-kinase anchoring protein 5
    Orthology source: HomoloGene
  • Synonyms
    AKAP75, AKAP79, H21
  • Links
    NCBI Gene ID: 9495
    neXtProt AC: NX_P24588

  • Chr Location
    14q23.3; chr14:64465499-64474503 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 6 alleles in 7 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    10
  • Genomic Mutations
    1 involving Akap5
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit reduced long term potentiation, improved glucose handling and heightened insulin sensitivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016317 VEGA Gene Model | MGI Sequence Detail 9263 C57BL/6J ±  kb
transcript OTTMUST00000039217 VEGA | MGI Sequence Detail 6687 Not Applicable  
polypeptide OTTMUSP00000017521 VEGA | MGI Sequence Detail 752 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    83 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000003892 A-kinase anchor protein 5
  • InterPro Domains
    IPR001573 Protein kinase A anchoring, WSK motif
Molecular
Reagents
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  • All nucleic 18
    cDNA 18

    Microarray probesets 2
Other
Accession IDs
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MGI:1918024, MGI:2145066
References
more
  • Summaries
    All 55
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 27
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:230855 Sanderson JL, et al., NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca(2+)-Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin. Neuron. 2016 Mar 2;89(5):1000-15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory