Akap5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Akap5
A kinase anchor protein 5
MGI:2685104

20 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Akap5^tm1.1Jsco/Akap5^tm1.1Jsco involves: 129S * C57BL/6	abnormal pancreatic beta cell morphology	J:190017
	decreased circulating insulin level	J:190017
	decreased insulin secretion	J:190017
	improved glucose tolerance	J:190017
	increased insulin sensitivity	J:190017
Akap5^tm1.1Jsco/Akap5^tm1.1Jsco involves: 129S * C57BL/6 * FVB/N	abnormal AMPA-mediated synaptic currents	J:138972
	abnormal spatial learning	J:138972
	decreased anxiety-related response	J:138972
	decreased susceptibility to pharmacologically induced seizures	J:138972
	impaired coordination	J:138972
	reduced long-term depression	J:138972
Akap5^tm1Gsm/Akap5^tm1Gsm B6.129-Akap5^tm1Gsm	reduced long-term potentiation	J:127739
Akap5^tm1Gsm/Akap5^tm1Gsm involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	decreased circulating insulin level	J:190017
	normal homeostasis/metabolism phenotype	J:190017
Akap5^tm1Jsco/Akap5^tm1Jsco Tg(Ins2-cre)25Mgn/0 involves: 129S * C57BL/6 * DBA	decreased circulating insulin level	J:190017
	impaired glucose tolerance	J:190017
	increased insulin secretion	J:190017
Akap5^tm1Mdaq/Akap5^tm1Mdaq involves: 129 * C57BL/6	abnormal AMPA-mediated synaptic currents	J:191219
	abnormal excitatory postsynaptic potential	J:191219
	abnormal synaptic plasticity	J:191219
	absent long-term depression	J:191219
	enhanced long-term potentiation	J:191219
	normal nervous system phenotype	J:191219
	reduced long-term depression	J:191219
Akap5^tm1Mdaq/Akap5^tm1Mdaq involves: 129 * C57BL/6 * C57BL/6J	decreased circulating insulin level	J:190017
	decreased insulin secretion	J:190017
	improved glucose tolerance	J:190017
	increased insulin sensitivity	J:190017
Akap5^tm2Mdaq/Akap5^tm2Mdaq involves: 129 * C57BL/6	abnormal synaptic plasticity	J:211790

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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