Akap5^tm2Mdaq
Targeted Allele Detail

Summary

• Symbol: Akap5^tm2Mdaq
• Name: A kinase anchor protein 5; targeted mutation 2, Mark Dell'Acqua
• MGI ID: MGI:5635498
• Synonyms: AKAP150deltaPKA, Akap5^-, Akap5^{709-LLIETASSLV-718}, Akap5^tm3Jsco
• Gene: Akap5 Location: Chr12:76371665-76380927 bp, + strand Genetic Position: Chr12, 33.73 cM
• Alliance: Akap5^tm2Mdaq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211790
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 30 bp sequence in the coding exon encoding 709-LLIETASSLV-718 was removed and a myc-epitope tag was inserted in-frame at the 3' of the coding exon. A loxP-flanked neomycin cassette downstream of the coding exon was removed via Cre-mediated recombination.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akap5 Mutation: 27 strains or lines available

References

• Original: J:211790 Murphy JG, et al., AKAP-anchored PKA maintains neuronal L-type calcium channel activity and NFAT transcriptional signaling. Cell Rep. 2014 Jun 12;7(5):1577-88
• All: 4 reference(s)