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Leo1 Gene Detail
Summary
  • Symbol
    Leo1
  • Name
    Leo1, Paf1/RNA polymerase II complex component
  • Synonyms
    LOC235497
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685031
    NCBI Gene: 235497
  • Gene Overview
    MyGene.info: LEO1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:75441524-75466432 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 42.30 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    278 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685031
protein coding gene Chr9:75441014-75466432 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035040
protein coding gene Chr9:75755117-75781988 (+)
A/J MGP_AJ_G0035021
protein coding gene Chr9:73111168-73135799 (+)
AKR/J MGP_AKRJ_G0034950
protein coding gene Chr9:74856505-74881162 (+)
BALB/cJ MGP_BALBcJ_G0035013
protein coding gene Chr9:72780186-72805434 (+)
C3H/HeJ MGP_C3HHeJ_G0034722
protein coding gene Chr9:75321894-75349571 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035531
protein coding gene Chr9:77766511-77791319 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032442
protein coding gene Chr9:72471733-72495728 (+)
CAST/EiJ MGP_CASTEiJ_G0034044
protein coding gene Chr9:75669718-75696133 (+)
CBA/J MGP_CBAJ_G0034694
protein coding gene Chr9:80432902-80460466 (+)
DBA/2J MGP_DBA2J_G0034854
protein coding gene Chr9:72781140-72806124 (+)
FVB/NJ MGP_FVBNJ_G0034796
protein coding gene Chr9:72080073-72105071 (+)
LP/J MGP_LPJ_G0034935
protein coding gene Chr9:76003118-76030155 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034837
protein coding gene Chr9:81512042-81537777 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035554
protein coding gene Chr9:75008321-75034146 (+)
PWK/PhJ MGP_PWKPhJ_G0033748
protein coding gene Chr9:73063183-73089941 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033581
protein coding gene Chr9:75246864-75274880 (+)
WSB/EiJ MGP_WSBEiJ_G0034156
protein coding gene Chr9:74929783-74955409 (+)



Homology
more
  • Human Ortholog
    LEO1, LEO1 homolog, Paf1/RNA polymerase II complex component
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LEO1, LEO1 homolog, Paf1/RNA polymerase II complex component
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RDL
  • Links
    NCBI Gene ID: 123169
    neXtProt AC: NX_Q8WVC0
    UniProt: Q8WVC0

  • Chr Location
    15q21.2; chr15:51938024-51971801 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042487 Ensembl Gene Model | MGI Sequence Detail 24909 C57BL/6J ±  kb
transcript ENSMUST00000048937 Ensembl | MGI Sequence Detail 2180 Not Applicable  
polypeptide ENSMUSP00000046905 Ensembl | MGI Sequence Detail 667 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:65653 Wertz K, et al., Large-scale screen for genes involved in gonad development. Mech Dev. 2000 Nov;98(1-2):51-70
  • Latest
    J:237500 Osipovich AB, et al., Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation. Development. 2016 Dec 15;143(24):4595-4607

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory