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Tmem231
Gene Detail
 Symbol
Name
ID
Tmem231
transmembrane protein 231
MGI:2685024
Synonyms 4932417I16Rik
Feature Type protein coding gene
Genetic Map
Chromosome 8
58.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:111912018-111933791 bp, - strand
From NCBI annotation of GRCm38

  21774 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:78035  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tmem231

Human
homologs
Human Homolog TMEM231, transmembrane protein 231
NCBI Gene ID 79583
neXtProt AC  NX_Q9H6L2
Human Synonyms  ALYE870, JBTS20, MKS11, PRO1886
Human Chr (Location)  16q23.1; chr16:75538117-75556286 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human TMEM231
Alleles
and
phenotypes
All alleles(228) : Targeted(1) Gene trapped(227)
 
Mice homozygous for a gene trapped allele exhibit complete lethality throughout fetal growth and development, defective patterning of the ventral spinal cord, a striking loss in cilia, severe vascular defects, polydactyly, and microphthalmia.
 
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process camera-type eye development, cell projection organization, ...
Component cell projection, ciliary membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031951 (Evidence)
Entrez Gene234740 (Evidence)
DFCITC1578467, TC1624774, TC1633689
DoTSDT.101720365, DT.60105261, DT.91320251
NIA Mouse Gene IndexU030273
Consensus CDS ProjectCCDS52676.1
International Mouse Knockout Project StatusTmem231
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 234740 NCBI Gene Model | MGI Sequence Detail 21774 C57BL/6J ±  kb
transcript NM_001033321 RefSeq | MGI Sequence Detail 2887 NOD 
polypeptide Q3U284 UniProt | EBI | MGI Sequence Detail 315 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(171 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019306 Transmembrane protein 231
Protein Ontology PR:000031334 transmembrane protein 231
Graphical View of Protein Domain Structure
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:178978 Chih B, et al., A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Nat Cell Biol. 2011;14(1):61-72
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory