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Tmem231
Gene Detail
Symbol

Name
ID
Tmem231
transmembrane protein 231
MGI:2685024
Synonyms
4932417I16Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 8
58.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:111912018-111933791 bp, - strand
From Ensembl annotation of GRCm38

  21774 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:78035  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TMEM231
Gene Tree: Tmem231

Human
homologs
TMEM231, transmembrane protein 231
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 79583
neXtProt AC: NX_Q9H6L2

Human Synonyms: ALYE870, JBTS20, MKS11, PRO1886

Human Chr (Location): 16q23.1; chr16:75538117-75556286 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human TMEM231

Mutations,
alleles, and
phenotypes
All mutations/alleles(228) : Gene trapped(227) Targeted(1)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a gene trapped allele exhibit complete lethality throughout fetal growth and development, defective patterning of the ventral spinal cord, a striking loss in cilia, severe vascular defects, polydactyly, and microphthalmia.
 
Interactions
Tmem231 interacts with 212 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process camera-type eye development, cell projection organization, ...
Component cell projection, ciliary membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tmem231 ; ZFIN tmem231    NEW 
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000031951 (Evidence)
Entrez Gene 234740 (Evidence)
DFCI TC1578467, TC1624774, TC1633689
DoTS DT.101720365, DT.60105261, DT.91320251
NIA Mouse Gene Index U030273
Consensus CDS Project CCDS52676.1
International Mouse Phenotyping Consortium Status Tmem231
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031951 Ensembl Gene Model | MGI Sequence Detail 21774 C57BL/6J ±  kb
transcript ENSMUST00000034429 Ensembl | MGI Sequence Detail 2887 Not Applicable 
polypeptide ENSMUSP00000034429 Ensembl | MGI Sequence Detail 315 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(8) UniProt(1)
Polymorphisms
SNPs within 2kb(171 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019306 Transmembrane protein 231
Protein Ontology PR:000031334 transmembrane protein 231
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:178978 Chih B, et al., A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Nat Cell Biol. 2011;14(1):61-72
All references(25)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory