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Tmem231 Gene Detail
Summary
  • Symbol
    Tmem231
  • Name
    transmembrane protein 231
  • Synonyms
    4932417I16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685024
    NCBI Gene: 234740
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:112638639-112660445 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 58.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    171 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685024
 protein coding gene Chr8:112638639-112660513 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034149
 protein coding gene Chr8:114744756-114766652 (-)
A/J MGP_AJ_G0034129
 protein coding gene Chr8:110060158-110081972 (-)
AKR/J MGP_AKRJ_G0034056
 protein coding gene Chr8:113300288-113325505 (-)
BALB/cJ MGP_BALBcJ_G0034123
 protein coding gene Chr8:110238447-110260132 (-)
C3H/HeJ MGP_C3HHeJ_G0033834
 protein coding gene Chr8:114013073-114034874 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034643
 protein coding gene Chr8:118750776-118774517 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031585
 protein coding gene Chr8:103132695-103154680 (-)
CAST/EiJ MGP_CASTEiJ_G0033161
 protein coding gene Chr8:113659783-113682163 (-)
CBA/J MGP_CBAJ_G0033807
 protein coding gene Chr8:122853585-122875233 (-)
DBA/2J MGP_DBA2J_G0033963
 protein coding gene Chr8:109333107-109356449 (-)
FVB/NJ MGP_FVBNJ_G0033906
 protein coding gene Chr8:108316462-108338116 (-)
LP/J MGP_LPJ_G0034052
 protein coding gene Chr8:114900355-114923071 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033953
 protein coding gene Chr8:125680148-125704380 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034661
 protein coding gene Chr8:113286611-113310877 (-)
PWK/PhJ MGP_PWKPhJ_G0032863
 protein coding gene Chr8:108947195-108969765 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032703
 protein coding gene Chr8:111942355-111968516 (-)
WSB/EiJ MGP_WSBEiJ_G0033277
 protein coding gene Chr8:113967825-113992360 (-)



Homology
more
  • Human Ortholog
    TMEM231, transmembrane protein 231
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM231, transmembrane protein 231
  • Synonyms
    ALYE870, JBTS20, MKS11, PRO1886
  • Links
    NCBI Gene ID: 79583
    neXtProt AC: NX_Q9H6L2
    UniProt: Q9H6L2

  • Chr Location
    16q23.1; chr16:75536741-75556289 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TMEM231 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit complete lethality throughout fetal growth and development, defective patterning of the ventral spinal cord, a striking loss in cilia, severe vascular defects, polydactyly, and microphthalmia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    8
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 234740 NCBI Gene Model | MGI Sequence Detail 21807 C57BL/6J ±  kb
    transcript NM_001357348 RefSeq | MGI Sequence Detail 3003 C57BL/6  
    polypeptide Q3U284 UniProt | EBI | MGI Sequence Detail 315 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 3
    References
    more
    • Summaries
      All 25
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 7
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:314668 Abrams SR, et al., Ciliary Hedgehog signaling regulates cell survival to build the facial midline. Elife. 2021 Oct 21;10:e68558
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory