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Tmem231
Gene Detail
Symbol

Name
ID
Tmem231
transmembrane protein 231
MGI:2685024
Synonyms
4932417I16Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 8
58.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:111912018-111933791 bp, - strand
From Ensembl annotation of GRCm38

  21774 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:78035  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tmem231

Human
homologs
Human Homolog TMEM231, transmembrane protein 231
NCBI Gene ID 79583
neXtProt AC  NX_Q9H6L2
Human Synonyms  ALYE870, JBTS20, MKS11, PRO1886
Human Chr (Location)  16q23.1; chr16:75538117-75556286 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human TMEM231
Mutations,
alleles, and
phenotypes
All mutations/alleles(228) : Gene trapped(227) Targeted(1)
Incidental mutations (data from APF )
 
Mice homozygous for a gene trapped allele exhibit complete lethality throughout fetal growth and development, defective patterning of the ventral spinal cord, a striking loss in cilia, severe vascular defects, polydactyly, and microphthalmia.
 
Interactions
Tmem231 interacts with 213 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process camera-type eye development, cell projection organization, ...
Component cell projection, ciliary membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031951 (Evidence)
Entrez Gene234740 (Evidence)
DFCITC1633689, TC1624774, TC1578467
DoTSDT.101720365, DT.60105261, DT.91320251
NIA Mouse Gene IndexU030273
Consensus CDS ProjectCCDS52676.1
International Mouse Knockout Project StatusTmem231
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031951 Ensembl Gene Model | MGI Sequence Detail 21774 C57BL/6J ±  kb
transcript ENSMUST00000034429 Ensembl | MGI Sequence Detail 2887 Not Applicable 
polypeptide ENSMUSP00000034429 Ensembl | MGI Sequence Detail 315 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(171 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019306 Transmembrane protein 231
Protein Ontology PR:000031334 transmembrane protein 231
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:178978 Chih B, et al., A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Nat Cell Biol. 2011;14(1):61-72
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory