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Lclat1 Gene Detail
Summary
  • Symbol
    Lclat1
  • Name
    lysocardiolipin acyltransferase 1
  • Synonyms
    AGPAT8, ALCAT1, Lycat
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684937
    NCBI Gene: 225010
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:73107985-73243368 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      135384 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 44.79 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LCLAT1, lysocardiolipin acyltransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LCLAT1, lysocardiolipin acyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    1AGPAT8, AGPAT8, ALCAT1, HSRG1849, LYCAT, UNQ1849
  • Links
    NCBI Gene ID: 253558
    neXtProt AC: NX_Q6UWP7
    UniProt: Q6UWP7

  • Chr Location
    2p23.1; chr2:30447226-30644225 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a knock-out allele and fed a high fat diet exhibit resistance to diet induced obesity, decreased total body fat, increased insulin sensitivity, polyphagia, hyperactivity, increased energy expenditure, and increased fatty acid oxidation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000031573 VEGA Gene Model | MGI Sequence Detail 135384 C57BL/6J ±  kb
    transcript OTTMUST00000078197 VEGA | MGI Sequence Detail 4467 Not Applicable  
    polypeptide OTTMUSP00000041562 VEGA | MGI Sequence Detail 376 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      365 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 64
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146804
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:246969 Zou C, et al., LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1. J Cell Sci. 2016 Jan 01;129(1):51-64

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory