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Lclat1
Gene Detail
 Symbol
Name
ID
Lclat1
lysocardiolipin acyltransferase 1
MGI:2684937
Synonyms AGPAT8, ALCAT1, Lycat
Feature Type protein coding gene
Genetic Map
Chromosome 17
44.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:73107985-73243368 bp, + strand
From VEGA annotation of GRCm38

  135384 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:33167  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 1-acyl-sn-glycerol-3-phosphate acyltransferase-like protein
Gene Tree: Lclat1

Human
homologs
Human Homolog LCLAT1, lysocardiolipin acyltransferase 1
NCBI Gene ID 253558
neXtProt AC  NX_Q6UWP7
Human Synonyms  1AGPAT8, AGPAT8, ALCAT1, HSRG1849, LYCAT, UNQ1849
Human Chr (Location)  2p23.1; chr2:30447236-30644225 (+)  GRCh38
Alleles
and
phenotypes
All alleles(15) : Targeted(3) Gene trapped(12)
 
Male mice homozygous for a knock-out allele and fed a high fat diet exhibit resistance to diet induced obesity, decreased total body fat, increased insulin sensitivity, polyphagia, hyperactivity, increased energy expenditure, and increased fatty acid oxidation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process lipid metabolic process, metabolic process, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function 1-acylglycerol-3-phosphate O-acyltransferase activity, transferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (139)    Tissues (134)    Images (10)
Theiler Stages: 15, 17, 19, 20, 22, 24, 28
Assay TypeResults
RNA in situ 125
RT-PCR 14
cDNA source data(64)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(67) cDNA(64) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000031573 (Evidence)
Ensembl Gene ModelENSMUSG00000054469 (Evidence)
Entrez Gene225010 (Evidence)
UniGene329194
DFCITC1641429, TC1696946
DoTSDT.489969, DT.55121253, DT.97334930
NIA Mouse Gene IndexU018216
EC2.3.1.-, 2.3.1.51
Consensus CDS ProjectCCDS37689.1
International Mouse Knockout Project StatusLclat1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031573 VEGA Gene Model | MGI Sequence Detail 135384 C57BL/6J ±  kb
transcript OTTMUST00000078197 VEGA | MGI Sequence Detail 4467 Not Applicable 
polypeptide OTTMUSP00000041562 VEGA | MGI Sequence Detail 376 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(8) UniProt(4)
Polymorphisms SNPs within 2kb(371 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002123 Phospholipid/glycerol acyltransferase
Protein Ontology PR:000009718 lysocardiolipin acyltransferase 1
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:189243 Liu X, et al., Ablation of ALCAT1 Mitigates Hypertrophic Cardiomyopathy through Effects on Oxidative Stress and Mitophagy. Mol Cell Biol. 2012 Nov;32(21):4493-504
All references(42)
Other
accession IDs
MGI:2146804

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory