Lclat1
Gene Detail

Symbol Name ID

Lclat1 lysocardiolipin acyltransferase 1 MGI:2684937

Synonyms

AGPAT8, ALCAT1, Lycat

Feature Type

protein coding gene

Genetic Map

Chromosome 17

44.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:73107985-73243368 bp, + strand From VEGA annotation of GRCm38   135384 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:33167  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 1-acyl-sn-glycerol-3-phosphate acyltransferase-like protein
Gene Tree: Lclat1

Human homologs

Human Homolog		LCLAT1, lysocardiolipin acyltransferase 1
NCBI Gene ID		253558
neXtProt AC		NX_Q6UWP7
Human Synonyms		1AGPAT8, AGPAT8, ALCAT1, HSRG1849, LYCAT, UNQ1849
Human Chr (Location)		2p23.1; chr2:30670123-30867091 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(15) : Targeted(3) Gene trapped(12)
 

Male mice homozygous for a knock-out allele and fed a high fat diet exhibit resistance to diet induced obesity, decreased total body fat, increased insulin sensitivity, polyphagia, hyperactivity, increased energy expenditure, and increased fatty acid oxidation.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	lipid metabolic process, metabolic process, ...
Component	endoplasmic reticulum, integral to membrane, ...
Function	1-acylglycerol-3-phosphate O-acyltransferase activity, transferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (139)    Tissues (134)    Images (10)
Theiler Stages: 15, 17, 19, 20, 22, 24, 28

Assay Type	Results
RNA in situ	125
RT-PCR	14

cDNA source data(63)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(66) cDNA(63) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000031573 (Evidence)
Ensembl Gene Model	ENSMUSG00000054469 (Evidence)
Entrez Gene	225010 (Evidence)
UniGene	329194
DFCI	TC1641429, TC1696946
DoTS	DT.489969, DT.55121253, DT.97334930
NIA Mouse Gene Index	U018216
EC	2.3.1.-, 2.3.1.51
Consensus CDS Project	CCDS37689.1
International Mouse Knockout Project Status	Lclat1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031573	VEGA Gene Model | MGI Sequence Detail	135384	C57BL/6J
transcript	OTTMUST00000078197	VEGA | MGI Sequence Detail	4467	Not Applicable
polypeptide	OTTMUSP00000041562	VEGA | MGI Sequence Detail	376	Not Applicable

All sequences(45) RefSeq(6) UniProt(4)

Polymorphisms

SNPs(284 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002123	Phospholipid/glycerol acyltransferase
Protein Ontology	PR:000009718	lysocardiolipin acyltransferase 1

References

(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:189243 Liu X, et al., Ablation of ALCAT1 Mitigates Hypertrophic Cardiomyopathy through Effects on Oxidative Stress and Mitophagy. Mol Cell Biol. 2012 Nov;32(21):4493-504
All references(41)

Other accession IDs

MGI:2146804